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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Mori, S, Chang, JT, Andrechek, ER, Matsumura, N, Baba, T, Yao, G, Kim, JW, Gatza, M, Murphy, S, and Nevins, JR. "Anchorage-independent cell growth signature identifies tumors with metastatic potential." Oncogene 28, no. 31 (August 6, 2009): 2796-2805.

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Ding, X, Mohd, AB, Huang, Z, Baba, T, Bernardini, MQ, Lyerly, HK, Berchuck, A, Murphy, SK, Buermeyer, AB, and Devi, GR. "MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition." Br J Cancer 101, no. 2 (July 21, 2009): 269-277.

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Huang, Z, Wen, Y, Simel, L, Price, T, Berchuck, A, and Murphy, SK. "CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer." CANCER RESEARCH 69 (May 1, 2009).

Scholars@Duke

Berchuck, A, Iversen, ES, Luo, J, Clarke, JP, Horne, H, Levine, DA, Boyd, J, Alonso, MA, Secord, AA, Bernardini, MQ, Barnett, JC, Boren, T, Murphy, SK, Dressman, HK, Marks, JR, and Lancaster, JM. "Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome." Clin Cancer Res 15, no. 7 (April 1, 2009): 2448-2455.

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Kondoh, E, Okamoto, T, Higuchi, T, Tatsumi, K, Baba, T, Murphy, SK, Takakura, K, Konishi, I, and Fujii, S. "Stress affects uterine receptivity through an ovarian-independent pathway." Hum Reprod 24, no. 4 (April 2009): 945-953.

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Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." March 2009.

Scholars@Duke

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium." March 2009.

Scholars@Duke

Kondoh, E, Baba, T, Malsumura, N, Konishi, I, Fujii, S, Berchuck, A, and Murphy, SK. "7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids." GYNECOLOGIC ONCOLOGY 112, no. 2 (February 2009): S161-S162.

Scholars@Duke

Yamaguchi, K, Mandai, M, Matsumura, N, Baba, T, Oura, T, Matsui, S, Murphy, SK, Berchuck, A, Fujii, S, and Konishi, I. "Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts." GYNECOLOGIC ONCOLOGY 112, no. 2 (February 2009): S132-S132.

Scholars@Duke

Barnett, JC, Kondoh, E, Whitaker, R, Murphy, SK, and Berchuck, A. "High poly (ADP-ribose) polymerase (PARP) expression is associated with poor survival in advanced-stage serous ovarian cancer." GYNECOLOGIC ONCOLOGY 112, no. 2 (February 2009): S107-S107.

Scholars@Duke

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