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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Barnett, JC, Bean, SM, Nakayama, JM, Kondoh, E, Murphy, SK, and Berchuck, A. "High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer." Obstet Gynecol 115, no. 1 (January 2010): 49-54.

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Hoyo, C, Schildkraut, JM, Murphy, SK, Chow, W-H, Vaughan, TL, Risch, H, Marks, JR, Jirtle, RL, Calingaert, B, Mayne, S, Fraumeni, J, and Gammon, MD. "IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas." Int J Cancer 125, no. 11 (December 1, 2009): 2673-2678.

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Gregory, SG, Connelly, JJ, Towers, AJ, Johnson, J, Biscocho, D, Markunas, CA, Lintas, C, Abramson, RK, Wright, HH, Ellis, P, Langford, CF, Worley, G, Delong, GR, Murphy, SK, Cuccaro, ML, Persico, A, and Pericak-Vance, MA. "Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. (Published online)" BMC Med 7 (October 22, 2009): 62-.

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Hoyo, C, Murphy, SK, and Jirtle, RL. "Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies." J Epidemiol Community Health 63, no. 9 (September 2009): 683-684.

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Mori, S, Chang, JT, Andrechek, ER, Matsumura, N, Baba, T, Yao, G, Kim, JW, Gatza, M, Murphy, S, and Nevins, JR. "Anchorage-independent cell growth signature identifies tumors with metastatic potential." Oncogene 28, no. 31 (August 2009): 2796-2805.

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Ding, X, Mohd, AB, Huang, Z, Baba, T, Bernardini, MQ, Lyerly, HK, Berchuck, A, Murphy, SK, Buermeyer, AB, and Devi, GR. "MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition." British Journal of Cancer 101, no. 2 (July 2009): 269-277.

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Huang, Z, Wen, Y, Simel, L, Price, T, Berchuck, A, and Murphy, SK. "CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer." CANCER RESEARCH 69 (May 1, 2009).

Scholars@Duke

Berchuck, A, Iversen, ES, Luo, J, Clarke, JP, Horne, H, Levine, DA, Boyd, J, Alonso, MA, Secord, AA, Bernardini, MQ, Barnett, JC, Boren, T, Murphy, SK, Dressman, HK, Marks, JR, and Lancaster, JM. "Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 7 (April 2009): 2448-2455.

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Kondoh, E, Okamoto, T, Higuchi, T, Tatsumi, K, Baba, T, Murphy, SK, Takakura, K, Konishi, I, and Fujii, S. "Stress affects uterine receptivity through an ovarian-independent pathway." Hum Reprod 24, no. 4 (April 2009): 945-953.

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Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

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