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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Ding, X, Mohd, AB, Huang, Z, Baba, T, Bernardini, MQ, Lyerly, HK, Berchuck, A, Murphy, SK, Buermeyer, AB, and Devi, GR. "MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition." British Journal of Cancer 101, no. 2 (July 2009): 269-277.

Full Text

Huang, Z, Wen, Y, Simel, L, Price, T, Berchuck, A, and Murphy, SK. "CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer." CANCER RESEARCH 69 (May 1, 2009).

Scholars@Duke

Berchuck, A, Iversen, ES, Luo, J, Clarke, JP, Horne, H, Levine, DA, Boyd, J, Alonso, MA, Secord, AA, Bernardini, MQ, Barnett, JC, Boren, T, Murphy, SK, Dressman, HK, Marks, JR, and Lancaster, JM. "Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 7 (April 2009): 2448-2455.

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Kondoh, E, Okamoto, T, Higuchi, T, Tatsumi, K, Baba, T, Murphy, SK, Takakura, K, Konishi, I, and Fujii, S. "Stress affects uterine receptivity through an ovarian-independent pathway." Hum Reprod 24, no. 4 (April 2009): 945-953.

Full Text

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

Murphy, SK, Jayes, FL, Feng, L, Huang, Z, and Leppert, PC. "Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium." March 2009.

Scholars@Duke

Horne, HN, Lee, PS, Murphy, SK, Alonso, MA, Olson, JA, and Marks, JR. "Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy." Molecular Cancer Research : Mcr 7, no. 2 (February 10, 2009): 199-209.

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Matsumura, N, Huang, Z, Baba, T, Lee, PS, Barnett, JC, Mori, S, Chang, JT, Kuo, W-L, Gusberg, AH, Whitaker, RS, Gray, JW, Fujii, S, Berchuck, A, and Murphy, SK. "Yin yang 1 modulates taxane response in epithelial ovarian cancer." Molecular Cancer Research : Mcr 7, no. 2 (February 10, 2009): 210-220.

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Kondoh, E, Baba, T, Malsumura, N, Konishi, I, Fujii, S, Berchuck, A, and Murphy, SK. "7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids." GYNECOLOGIC ONCOLOGY 112, no. 2 (February 2009): S161-S162.

Scholars@Duke

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