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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

O'Sullivan, FM, Murphy, SK, Simel, LR, McCann, A, Callanan, JJ, and Nolan, CM. "Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation." Evol Dev 9, no. 6 (November 2007): 579-589.

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Baba, T, Mori, S, Matsumura, N, Kariya, M, Murphy, SK, Kondoh, E, Kusakari, T, Kuroda, H, Mandai, M, Higuchi, T, Takakura, K, Fukuda, MN, and Fujii, S. "Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity." Biochem Biophys Res Commun 360, no. 2 (August 24, 2007): 363-369.

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Hempel, N, How, T, Dong, M, Murphy, SK, Fields, TA, and Blobe, GC. "Loss of betaglycan expression in ovarian cancer: role in motility and invasion." Cancer Res 67, no. 11 (June 1, 2007): 5231-5238.

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Spillman, MA, Lacy, J, Murphy, SK, Whitaker, RS, Grace, L, Teaberry, V, Marks, JR, and Berchuck, A. "Regulation of the metastasis suppressor gene MKK4 in ovarian cancer." Gynecol Oncol 105, no. 2 (May 2007): 312-320.

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Price, TM, Murphy, SK, and Younglai, EV. "Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors." Toxicol Sci 96, no. 2 (April 2007): 218-226. (Review)

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Risinger, JI, Chandramouli, GVR, Maxwell, GL, Custer, M, Pack, S, Loukinov, D, Aprelikova, O, Litzi, T, Schrump, DS, Murphy, SK, Berchuck, A, Lobanenkov, V, and Barrett, JC. "Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression." Clin Cancer Res 13, no. 6 (March 15, 2007): 1713-1719.

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Schildkraut, JM, Murphy, SK, Palmieri, RT, Iversen, E, Moorman, PG, Huang, Z, Halabi, S, Calingaert, B, Gusberg, A, Marks, JR, and Berchuck, A. "Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer." Cancer Epidemiol Biomarkers Prev 16, no. 3 (March 2007): 473-480.

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Goh, L, Murphy, SK, Muhkerjee, S, and Furey, TS. "Genomic sweeping for hypermethylated genes." Bioinformatics 23, no. 3 (February 1, 2007): 281-288.

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Weidman, JR, Dolinoy, DC, Murphy, SK, and Jirtle, RL. "Cancer susceptibility: epigenetic manifestation of environmental exposures." Cancer J 13, no. 1 (January 2007): 9-16. (Review)

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Murphy, SK, Huang, Z, Wen, Y, Spillman, MA, Whitaker, RS, Simel, LR, Nichols, TD, Marks, JR, and Berchuck, A. "Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer." Mol Cancer Res 4, no. 4 (April 2006): 283-292.

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