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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Kang, Hyun Sook, Tsukasa Baba, Masaki Mandai, Noriomi Matsumura, Junzo Hamanishi, Budiman Kharma, Eiji Kondoh, et al. “GPR54 is a target for suppression of metastasis in endometrial cancer..” Mol Cancer Ther 10, no. 4 (April 2011): 580–90. https://doi.org/10.1158/1535-7163.MCT-10-0763.

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Sfakianos, G., J. Yan, R. Whitaker, S. Murphy, and A. Berchuck. “Concordant gene expression profiles in matched primary and recurrent serous ovarian cancers predict platinum response.” Gynecologic Oncology 120 (March 2011): S46–S46. https://doi.org/10.1016/j.ygyno.2010.12.112.

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Yamaguchi, K., T. Baba, I. Konishi, N. Matsumura, S. Murphy, Z. Huang, and A. Berchuck. “Genes functionally regulated by methylation in ovarian cancer are involved in cell proliferation, development and morphogenesis.” Gynecologic Oncology 120 (March 2011): S69–S69. https://doi.org/10.1016/j.ygyno.2010.12.165.

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Yamaguchi, K., T. Baba, N. Matsumura, M. Mandai, I. Konishi, A. Berchuck, and S. Murphy. “Genomewide methylation analyses reveal a prominent role of HINF1 network genes, via hypomethylation, in ovarian clear cell carcinoma.” Gynecologic Oncology 120 (March 2011): S8–S8. https://doi.org/10.1016/j.ygyno.2010.12.021.

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Hoyo, Cathrine, Amy P. Murtha, Joellen M. Schildkraut, Michele R. Forman, Brian Calingaert, Wendy Demark-Wahnefried, Joanne Kurtzberg, Randy L. Jirtle, and Susan K. Murphy. “Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)..” Bmc Public Health 11, no. 1 (January 21, 2011). https://doi.org/10.1186/1471-2458-11-46.

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Matsumura, Noriomi, Zhiqing Huang, Seiichi Mori, Tsukasa Baba, Shingo Fujii, Ikuo Konishi, Edwin S. Iversen, Andrew Berchuck, and Susan K. Murphy. “Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer..” Genome Res 21, no. 1 (January 2011): 74–82. https://doi.org/10.1101/gr.108803.110.

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Matsumura, Noriomi, Masaki Mandai, Takako Okamoto, Ken Yamaguchi, Shogo Yamamura, Tomonori Oura, Tsukasa Baba, et al. “Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling..” Cancer Sci 101, no. 12 (December 2010): 2658–63. https://doi.org/10.1111/j.1349-7006.2010.01736.x.

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Bernardini, Marcus Q., Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Gregory P. Sfakianos, Angeles Alvarez Secord, Susan K. Murphy, Edwin Iversen, Jeffrey R. Marks, and Andrew Berchuck. “Expression signatures of TP53 mutations in serous ovarian cancers..” Bmc Cancer 10 (May 26, 2010). https://doi.org/10.1186/1471-2407-10-237.

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Kondoh, Eiji, Seiichi Mori, Ken Yamaguchi, Tsukasa Baba, Noriomi Matsumura, J. Cory Barnett, Regina S. Whitaker, et al. “Targeting slow-proliferating ovarian cancer cells..” Int J Cancer 126, no. 10 (May 15, 2010): 2448–56. https://doi.org/10.1002/ijc.24919.

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Yamaguchi, K., M. Mandai, T. Oura, N. Matsumura, J. Hamanishi, T. Baba, S. Matsui, S. K. Murphy, and I. Konishi. “Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes..” Oncogene 29, no. 12 (March 25, 2010): 1741–52. https://doi.org/10.1038/onc.2009.470.

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