Yamaguchi, K., T. Baba, I. Konishi, N. Matsumura, S. Murphy, Z. Huang, and A. Berchuck. “Genes functionally regulated by methylation in ovarian cancer are involved in cell proliferation, development and morphogenesis.” Gynecologic Oncology 120 (March 2011): S69–S69. https://doi.org/10.1016/j.ygyno.2010.12.165.
Susan Kay Murphy, PhD
My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.
Education and Training
- Ph.D., Wake Forest University, 1998
- B.A., University of North Carolina - Charlotte, 1992
Selected Grants and Awards
- Population Health Research Support IDIQ Base
- Duke Women's Reproductive Health Research Scholars
- Pharmacological Sciences Training Grant
- Duke University Program in Environmental Health
- Duke KURe Program
- Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Building Interdisciplinary Research Careers in Women's Health
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight
- Translational Research in Surgical Oncology
- Clarifying the role of tobacco retail outlets on maternal smoking during pregnancy and child secondhand smoke exposure
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer
- Organization and Function of Cellular Structure
- Pharmacological Sciences Training Program
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Epigenomics in insulin resistance associated overactive bladder
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease
- Duke University Program in Environmental Health
- Social adversities, epigenetics, and the obesity epidemic
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES)
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES)
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer
- Immune regulated amino acid pathways in Alzheimer's Disease
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer
- Cancer Biology Training Grant
- Obesity and deregulation of imprinted genes in early life
- Epigenetic influence on the early childhood self-regulation capacities and obesity
- Ovarian Cancer Initiating Cells: Metabolic Characterization
- Gene Regulation in Recurrent Ovarian Cancers
- Disparities in cervical cancer precursors and deregulation of imprinted genes
- Nutrition, Deregulation of Imprinted Genes and Rapid Weight Gain in Early Life
- Characterizing Alcohol's Effects on Repair of Liver Injury
- Identification and Characterization of Epigenetically Labile Genes
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis
Yamaguchi, K., T. Baba, N. Matsumura, M. Mandai, I. Konishi, A. Berchuck, and S. Murphy. “Genomewide methylation analyses reveal a prominent role of HINF1 network genes, via hypomethylation, in ovarian clear cell carcinoma.” Gynecologic Oncology 120 (March 2011): S8–S8. https://doi.org/10.1016/j.ygyno.2010.12.021.
Hoyo, Cathrine, Amy P. Murtha, Joellen M. Schildkraut, Michele R. Forman, Brian Calingaert, Wendy Demark-Wahnefried, Joanne Kurtzberg, Randy L. Jirtle, and Susan K. Murphy. “Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).” Bmc Public Health 11, no. 1 (January 21, 2011): 46. https://doi.org/10.1186/1471-2458-11-46.
Matsumura, Noriomi, Zhiqing Huang, Seiichi Mori, Tsukasa Baba, Shingo Fujii, Ikuo Konishi, Edwin S. Iversen, Andrew Berchuck, and Susan K. Murphy. “Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.” Genome Res 21, no. 1 (January 2011): 74–82. https://doi.org/10.1101/gr.108803.110.
Matsumura, Noriomi, Masaki Mandai, Takako Okamoto, Ken Yamaguchi, Shogo Yamamura, Tomonori Oura, Tsukasa Baba, et al. “Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.” Cancer Sci 101, no. 12 (December 2010): 2658–63. https://doi.org/10.1111/j.1349-7006.2010.01736.x.
Bernardini, Marcus Q., Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Gregory P. Sfakianos, Angeles Alvarez Secord, Susan K. Murphy, Edwin Iversen, Jeffrey R. Marks, and Andrew Berchuck. “Expression signatures of TP53 mutations in serous ovarian cancers.” Bmc Cancer 10 (May 26, 2010): 237. https://doi.org/10.1186/1471-2407-10-237.
Yamaguchi, K., M. Mandai, T. Oura, N. Matsumura, J. Hamanishi, T. Baba, S. Matsui, S. K. Murphy, and I. Konishi. “Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes.” Oncogene 29, no. 12 (March 25, 2010): 1741–52. https://doi.org/10.1038/onc.2009.470.
Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.” Int J Cancer 126, no. 6 (March 15, 2010): 1378–89. https://doi.org/10.1002/ijc.24797.
Sfakianos, G., K. Yamaguchi, S. Murphy, and A. Berchuck. “Gene expression profiling of invasive serous ovarian cancers from formalin-fixed, paraffin-embedded tissues using DASL.” Gynecologic Oncology 116, no. 3 (March 1, 2010): S136–37.