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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer..” Int J Cancer 126, no. 6 (March 15, 2010): 1378–89. https://doi.org/10.1002/ijc.24797.

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Sfakianos, G., K. Yamaguchi, S. Murphy, and A. Berchuck. “Gene expression profiling of invasive serous ovarian cancers from formalin-fixed, paraffin-embedded tissues using DASL.” Gynecologic Oncology 116, no. 3 (March 1, 2010): S136–37.

Scholars@Duke

Baba, T., H. Kang, M. Mandai, J. Hamanishi, B. Kharma, N. Matsumura, K. Yamaguchi, S. Murphy, and I. Konishi. “Metastin-10 suppresses invasion of endometrial cancer cells.” In Gynecologic Oncology, 116:S76–S76. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.

Scholars@Duke

Barnett, Jason C., Sarah M. Bean, Regina S. Whitaker, Eiji Kondoh, Tsukasa Baba, Shingo Fujii, Jeffrey R. Marks, Holly K. Dressman, Susan K. Murphy, and Andrew Berchuck. “Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype..” Gynecol Oncol 116, no. 3 (March 2010): 556–62. https://doi.org/10.1016/j.ygyno.2009.11.020.

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Murphy, S., F. Overcash, Z. Huang, B. Vasquez, B. Hernandez, J. Obure, P. Mlay, O. Olola, J. Bartlett, and C. Hoyo. “Progressive epigenetic deregulation of insulin-like growth factor 2 in cervical cancer precursors in HIV plus and HIV- patients.” In Gynecologic Oncology, 116:S38–S38. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.

Scholars@Duke

Matsumura, N., M. Mandai, T. Okamoto, K. Yamaguchi, T. Oura, T. Baba, S. Mori, S. Murphy, and I. Konishi. “Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.” In Gynecologic Oncology, 116:S155–S155. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.

Scholars@Duke

Barnett, Jason C., Sarah M. Bean, John M. Nakayama, Eiji Kondoh, Susan K. Murphy, and Andrew Berchuck. “High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer..” Obstet Gynecol 115, no. 1 (January 2010): 49–54. https://doi.org/10.1097/AOG.0b013e3181c2d294.

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Fortner, Kimberly, Amy Murtha, Cathrine Hoyo, Francine Overcash, Zhiquing Huang, Joellen Schildkraut, Joanne Kurtzberg, Randy Jirtle, Michele Forman, and Susan Murphy. “70: Epigenetic orchestration of circulating insulin-like growth factor-2 levels in cord blood.” In American Journal of Obstetrics and Gynecology, 201:S39–S39. Elsevier BV, 2009. https://doi.org/10.1016/j.ajog.2009.10.085.

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Hoyo, Cathrine, Joellen M. Schildkraut, Susan K. Murphy, Wong-Ho Chow, Thomas L. Vaughan, Harvey Risch, Jeffrey R. Marks, et al. “IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas..” Int J Cancer 125, no. 11 (December 1, 2009): 2673–78. https://doi.org/10.1002/ijc.24623.

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