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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Yamaguchi, K., T. Baba, I. Konishi, N. Matsumura, S. Murphy, Z. Huang, and A. Berchuck. “Genes functionally regulated by methylation in ovarian cancer are involved in cell proliferation, development and morphogenesis.” Gynecologic Oncology 120 (March 2011): S69–S69. https://doi.org/10.1016/j.ygyno.2010.12.165.

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Yamaguchi, K., T. Baba, N. Matsumura, M. Mandai, I. Konishi, A. Berchuck, and S. Murphy. “Genomewide methylation analyses reveal a prominent role of HINF1 network genes, via hypomethylation, in ovarian clear cell carcinoma.” Gynecologic Oncology 120 (March 2011): S8–S8. https://doi.org/10.1016/j.ygyno.2010.12.021.

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Hoyo, Cathrine, Amy P. Murtha, Joellen M. Schildkraut, Michele R. Forman, Brian Calingaert, Wendy Demark-Wahnefried, Joanne Kurtzberg, Randy L. Jirtle, and Susan K. Murphy. “Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).” Bmc Public Health 11, no. 1 (January 21, 2011): 46. https://doi.org/10.1186/1471-2458-11-46.

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Matsumura, Noriomi, Zhiqing Huang, Seiichi Mori, Tsukasa Baba, Shingo Fujii, Ikuo Konishi, Edwin S. Iversen, Andrew Berchuck, and Susan K. Murphy. “Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.” Genome Res 21, no. 1 (January 2011): 74–82. https://doi.org/10.1101/gr.108803.110.

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Matsumura, Noriomi, Masaki Mandai, Takako Okamoto, Ken Yamaguchi, Shogo Yamamura, Tomonori Oura, Tsukasa Baba, et al. “Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.” Cancer Sci 101, no. 12 (December 2010): 2658–63. https://doi.org/10.1111/j.1349-7006.2010.01736.x.

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Bernardini, Marcus Q., Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Gregory P. Sfakianos, Angeles Alvarez Secord, Susan K. Murphy, Edwin Iversen, Jeffrey R. Marks, and Andrew Berchuck. “Expression signatures of TP53 mutations in serous ovarian cancers.” Bmc Cancer 10 (May 26, 2010): 237. https://doi.org/10.1186/1471-2407-10-237.

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Kondoh, Eiji, Seiichi Mori, Ken Yamaguchi, Tsukasa Baba, Noriomi Matsumura, J. Cory Barnett, Regina S. Whitaker, et al. “Targeting slow-proliferating ovarian cancer cells.” Int J Cancer 126, no. 10 (May 15, 2010): 2448–56. https://doi.org/10.1002/ijc.24919.

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Yamaguchi, K., M. Mandai, T. Oura, N. Matsumura, J. Hamanishi, T. Baba, S. Matsui, S. K. Murphy, and I. Konishi. “Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes.” Oncogene 29, no. 12 (March 25, 2010): 1741–52. https://doi.org/10.1038/onc.2009.470.

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Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.” Int J Cancer 126, no. 6 (March 15, 2010): 1378–89. https://doi.org/10.1002/ijc.24797.

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Sfakianos, G., K. Yamaguchi, S. Murphy, and A. Berchuck. “Gene expression profiling of invasive serous ovarian cancers from formalin-fixed, paraffin-embedded tissues using DASL.” Gynecologic Oncology 116, no. 3 (March 1, 2010): S136–37.

Scholars@Duke

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