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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Acharya, Kelly S., Rose Schrott, Edward Levin, and Susan K. Murphy. “Epigenetic Alterations in Cytochrome P450 Oxidoreductase (Por) in Sperm Exposed to Tetrahydrocannabinol (THC).” In Reproductive Sciences, 26:92A-92A. SAGE PUBLICATIONS INC, 2019.

Scholars@Duke

Fuemmeler, Bernard F., Nancy Zucker, Yaou Sheng, Carmen E. Sanchez, Rachel Maguire, Susan K. Murphy, Scott H. Kollins, and Cathrine Hoyo. “Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children.” Int J Environ Res Public Health 16, no. 4 (February 25, 2019). https://doi.org/10.3390/ijerph16040667.

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Do, E. K., N. L. Zucker, Z. Y. Huang, J. C. Schechter, S. H. Kollins, R. L. Maguire, S. K. Murphy, C. Hoyo, and B. F. Fuemmeler. “Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.” Pediatr Obes 14, no. 2 (February 2019): e12454. https://doi.org/10.1111/ijpo.12454.

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Sorrow, P., R. Maguire, S. K. Murphy, S. M. Belcher, and C. Hoyo. “Elevated metabolites of acetaminophen in cord blood of children with obesity.” Pediatr Obes 14, no. 1 (January 2019). https://doi.org/10.1111/ijpo.12465.

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Kantor, Boris, Lidia Tagliafierro, Jeffrey Gu, Madison E. Zamora, Ekaterina Ilich, Carole Grenier, Zhiqing Y. Huang, Susan Murphy, and Ornit Chiba-Falek. “Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.” Mol Ther 26, no. 11 (November 7, 2018): 2638–49. https://doi.org/10.1016/j.ymthe.2018.08.019.

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Moylan, Cynthia A., Patricia A. Sorrow, Alisha Mavis, Mustafa Bashir, Dereje Jima, Rachel Maguire, Erol Bozdogan, et al. “Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life.” In Hepatology, 68:949A-950A. WILEY, 2018.

Scholars@Duke

Gomih, Ayodele, Jennifer S. Smith, Kari E. North, Michael G. Hudgens, Wendy R. Brewster, Zhiqing Huang, David Skaar, et al. “DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.” Int J Cancer 143, no. 3 (August 1, 2018): 552–60. https://doi.org/10.1002/ijc.31350.

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Gao, Lu, Xiaochen Liu, Joshua Millstein, Kimberly D. Siegmund, Louis Dubeau, Rachel L. Maguire, Junfeng Jim Zhang, et al. “Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.” Clin Epigenetics 10, no. 1 (July 20, 2018): 98. https://doi.org/10.1186/s13148-018-0532-x.

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Green, Adrian J., Cathrine Hoyo, Carolyn J. Mattingly, Yiwen Luo, Jung-Ying Tzeng, Susan K. Murphy, David B. Buchwalter, and Antonio Planchart. “Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study.” Int J Obes (Lond) 42, no. 7 (July 2018): 1285–95. https://doi.org/10.1038/s41366-018-0036-y.

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Tindula, Gwen, Susan K. Murphy, Carole Grenier, Zhiqing Huang, Karen Huen, Maria Escudero-Fung, Asa Bradman, Brenda Eskenazi, Cathrine Hoyo, and Nina Holland. “DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.” In Epigenomics, 10:1011–26, 2018. https://doi.org/10.2217/epi-2017-0178.

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