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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Price, TM, Murphy, SK, and Younglai, EV. "Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors." Toxicological Sciences : an Official Journal of the Society of Toxicology 96, no. 2 (April 2007): 218-226. (Review)

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Risinger, JI, Chandramouli, GVR, Maxwell, GL, Custer, M, Pack, S, Loukinov, D, Aprelikova, O, Litzi, T, Schrump, DS, Murphy, SK, Berchuck, A, Lobanenkov, V, and Barrett, JC. "Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression." Clin Cancer Res 13, no. 6 (March 15, 2007): 1713-1719.

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Schildkraut, JM, Murphy, SK, Palmieri, RT, Iversen, E, Moorman, PG, Huang, Z, Halabi, S, Calingaert, B, Gusberg, A, Marks, JR, and Berchuck, A. "Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer." Cancer Epidemiol Biomarkers Prev 16, no. 3 (March 2007): 473-480.

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Goh, L, Murphy, SK, Muhkerjee, S, and Furey, TS. "Genomic sweeping for hypermethylated genes." Bioinformatics 23, no. 3 (February 1, 2007): 281-288.

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Weidman, JR, Dolinoy, DC, Murphy, SK, and Jirtle, RL. "Cancer susceptibility: epigenetic manifestation of environmental exposures." Cancer Journal (Sudbury, Mass.) 13, no. 1 (January 2007): 9-16. (Review)

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Murphy, SK, Huang, Z, Wen, Y, Spillman, MA, Whitaker, RS, Simel, LR, Nichols, TD, Marks, JR, and Berchuck, A. "Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer." Mol Cancer Res 4, no. 4 (April 2006): 283-292.

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Murphy, SK, Nolan, CM, Huang, Z, Kucera, KS, Freking, BA, Smith, TPL, Leymaster, KA, Weidman, JR, and Jirtle, RL. "Callipyge mutation affects gene expression in cis: a potential role for chromatin structure." Genome Research 16, no. 3 (March 2006): 340-346. (Letter)

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Huang, Z, Wen, Y, Shandilya, R, Marks, JR, Berchuck, A, and Murphy, SK. "High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. (Published online)" Nucleic Acids Res 34, no. 2 (2006): 555-563.

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Berchuck, A, Iversen, ES, Lancaster, JM, Pittman, J, Luo, J, Lee, P, Murphy, S, Dressman, HK, Febbo, PG, West, M, Nevins, JR, and Marks, JR. "Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers." Clin Cancer Res 11, no. 10 (May 15, 2005): 3686-3696.

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Spillman, MA, Schildkraut, JM, Halabi, S, Moorman, P, Calingaert, B, Bentley, RC, Marks, JR, Murphy, S, and Berchuck, A. "Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk." Gynecol Oncol 97, no. 2 (May 2005): 543-549.

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