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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Gregory, Simon G., Jessica J. Connelly, Aaron J. Towers, Jessica Johnson, Dhani Biscocho, Christina A. Markunas, Carla Lintas, et al. “Genomic and epigenetic evidence for oxytocin receptor deficiency in autism..” Bmc Med 7 (October 22, 2009). https://doi.org/10.1186/1741-7015-7-62.

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Hoyo, Cathrine, Susan K. Murphy, and Randy L. Jirtle. “Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies..” J Epidemiol Community Health 63, no. 9 (September 2009): 683–84. https://doi.org/10.1136/jech.2009.090803.

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Mori, S., J. T. Chang, E. R. Andrechek, N. Matsumura, T. Baba, G. Yao, J. W. Kim, M. Gatza, S. Murphy, and J. R. Nevins. “Anchorage-independent cell growth signature identifies tumors with metastatic potential..” Oncogene 28, no. 31 (August 6, 2009): 2796–2805. https://doi.org/10.1038/onc.2009.139.

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Ding, X., A. B. Mohd, Z. Huang, T. Baba, M. Q. Bernardini, H. K. Lyerly, A. Berchuck, S. K. Murphy, A. B. Buermeyer, and G. R. Devi. “MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition..” Br J Cancer 101, no. 2 (July 21, 2009): 269–77. https://doi.org/10.1038/sj.bjc.6605180.

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Huang, Zhiqing, Yaqing Wen, Lauren Simel, Thomas Price, Andrew Berchuck, and Susan K. Murphy. “CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer.” Cancer Research 69 (May 1, 2009).

Scholars@Duke

Kondoh, Eiji, Tsukasa Baba, Noriomi Matsumura, Ikuo Konishi, Shingo Fujii, Andrew Berchuck, and Susan Murphy. “UCN-01 is effective in targeting ovarian cancer spheroids.” Cancer Research 69 (May 1, 2009).

Scholars@Duke

Berchuck, Andrew, Edwin S. Iversen, Jingqin Luo, Jennifer P. Clarke, Hisani Horne, Douglas A. Levine, Jeff Boyd, et al. “Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome..” Clin Cancer Res 15, no. 7 (April 1, 2009): 2448–55. https://doi.org/10.1158/1078-0432.CCR-08-2430.

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Kondoh, Eiji, Takako Okamoto, Toshihiro Higuchi, Keiji Tatsumi, Tsukasa Baba, Susan K. Murphy, Kenji Takakura, Ikuo Konishi, and Shingo Fujii. “Stress affects uterine receptivity through an ovarian-independent pathway..” Hum Reprod 24, no. 4 (April 2009): 945–53. https://doi.org/10.1093/humrep/den461.

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Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium.” In Reproductive Sciences, 16:216A-216A. SAGE PUBLICATIONS INC, 2009.

Scholars@Duke

Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium.” In Reproductive Sciences, 16:214A-214A. SAGE PUBLICATIONS INC, 2009.

Scholars@Duke

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