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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Baba, T., H. Kang, M. Mandai, J. Hamanishi, B. Kharma, N. Matsumura, K. Yamaguchi, S. Murphy, and I. Konishi. “Metastin-10 suppresses invasion of endometrial cancer cells.” In Gynecologic Oncology, 116:S76–S76. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.

Scholars@Duke

Barnett, Jason C., Sarah M. Bean, Regina S. Whitaker, Eiji Kondoh, Tsukasa Baba, Shingo Fujii, Jeffrey R. Marks, Holly K. Dressman, Susan K. Murphy, and Andrew Berchuck. “Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.” Gynecol Oncol 116, no. 3 (March 2010): 556–62. https://doi.org/10.1016/j.ygyno.2009.11.020.

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Murphy, S., F. Overcash, Z. Huang, B. Vasquez, B. Hernandez, J. Obure, P. Mlay, O. Olola, J. Bartlett, and C. Hoyo. “Progressive epigenetic deregulation of insulin-like growth factor 2 in cervical cancer precursors in HIV plus and HIV- patients.” In Gynecologic Oncology, 116:S38–S38. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.

Scholars@Duke

Matsumura, N., M. Mandai, T. Okamoto, K. Yamaguchi, T. Oura, T. Baba, S. Mori, S. Murphy, and I. Konishi. “Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.” In Gynecologic Oncology, 116:S155–S155. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010.

Scholars@Duke

Barnett, Jason C., Sarah M. Bean, John M. Nakayama, Eiji Kondoh, Susan K. Murphy, and Andrew Berchuck. “High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.” Obstet Gynecol 115, no. 1 (January 2010): 49–54. https://doi.org/10.1097/AOG.0b013e3181c2d294.

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Fortner, Kimberly, Amy Murtha, Cathrine Hoyo, Francine Overcash, Zhiquing Huang, Joellen Schildkraut, Joanne Kurtzberg, Randy Jirtle, Michele Forman, and Susan Murphy. “70: Epigenetic orchestration of circulating insulin-like growth factor-2 levels in cord blood.” In American Journal of Obstetrics and Gynecology, 201:S39–S39. Elsevier BV, 2009. https://doi.org/10.1016/j.ajog.2009.10.085.

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Hoyo, Cathrine, Joellen M. Schildkraut, Susan K. Murphy, Wong-Ho Chow, Thomas L. Vaughan, Harvey Risch, Jeffrey R. Marks, et al. “IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.” Int J Cancer 125, no. 11 (December 1, 2009): 2673–78. https://doi.org/10.1002/ijc.24623.

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Gregory, Simon G., Jessica J. Connelly, Aaron J. Towers, Jessica Johnson, Dhani Biscocho, Christina A. Markunas, Carla Lintas, et al. “Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.” Bmc Med 7 (October 22, 2009): 62. https://doi.org/10.1186/1741-7015-7-62.

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Hoyo, Cathrine, Susan K. Murphy, and Randy L. Jirtle. “Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.” J Epidemiol Community Health 63, no. 9 (September 2009): 683–84. https://doi.org/10.1136/jech.2009.090803.

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