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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Mori, S., J. T. Chang, E. R. Andrechek, N. Matsumura, T. Baba, G. Yao, J. W. Kim, M. Gatza, S. Murphy, and J. R. Nevins. “Anchorage-independent cell growth signature identifies tumors with metastatic potential.” Oncogene 28, no. 31 (August 6, 2009): 2796–2805. https://doi.org/10.1038/onc.2009.139.

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Ding, X., A. B. Mohd, Z. Huang, T. Baba, M. Q. Bernardini, H. K. Lyerly, A. Berchuck, S. K. Murphy, A. B. Buermeyer, and G. R. Devi. “MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.” Br J Cancer 101, no. 2 (July 21, 2009): 269–77. https://doi.org/10.1038/sj.bjc.6605180.

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Huang, Zhiqing, Yaqing Wen, Lauren Simel, Thomas Price, Andrew Berchuck, and Susan K. Murphy. “CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer.” Cancer Research 69 (May 1, 2009).

Scholars@Duke

Kondoh, Eiji, Tsukasa Baba, Noriomi Matsumura, Ikuo Konishi, Shingo Fujii, Andrew Berchuck, and Susan Murphy. “UCN-01 is effective in targeting ovarian cancer spheroids.” Cancer Research 69 (May 1, 2009).

Scholars@Duke

Berchuck, Andrew, Edwin S. Iversen, Jingqin Luo, Jennifer P. Clarke, Hisani Horne, Douglas A. Levine, Jeff Boyd, et al. “Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.” Clin Cancer Res 15, no. 7 (April 1, 2009): 2448–55. https://doi.org/10.1158/1078-0432.CCR-08-2430.

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Kondoh, Eiji, Takako Okamoto, Toshihiro Higuchi, Keiji Tatsumi, Tsukasa Baba, Susan K. Murphy, Kenji Takakura, Ikuo Konishi, and Shingo Fujii. “Stress affects uterine receptivity through an ovarian-independent pathway.” Hum Reprod 24, no. 4 (April 2009): 945–53. https://doi.org/10.1093/humrep/den461.

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Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium.” In Reproductive Sciences, 16:216A-216A. SAGE PUBLICATIONS INC, 2009.

Scholars@Duke

Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium.” In Reproductive Sciences, 16:214A-214A. SAGE PUBLICATIONS INC, 2009.

Scholars@Duke

Kondoh, E., T. Baba, N. Malsumura, I. Konishi, S. Fujii, A. Berchuck, and S. K. Murphy. “7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids.” Gynecologic Oncology 112, no. 2 (February 1, 2009): S161–62.

Scholars@Duke

Yamaguchi, K., M. Mandai, N. Matsumura, T. Baba, T. Oura, S. Matsui, S. K. Murphy, A. Berchuck, S. Fujii, and I. Konishi. “Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts.” Gynecologic Oncology 112, no. 2 (February 1, 2009): S132–S132.

Scholars@Duke

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