Mori, S., J. T. Chang, E. R. Andrechek, N. Matsumura, T. Baba, G. Yao, J. W. Kim, M. Gatza, S. Murphy, and J. R. Nevins. “Anchorage-independent cell growth signature identifies tumors with metastatic potential.” Oncogene 28, no. 31 (August 6, 2009): 2796–2805. https://doi.org/10.1038/onc.2009.139.
Susan Kay Murphy, PhD
My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.
Education and Training
- Ph.D., Wake Forest University, 1998
- B.A., University of North Carolina - Charlotte, 1992
Selected Grants and Awards
- Population Health Research Support IDIQ Base
- Duke Women's Reproductive Health Research Scholars
- Pharmacological Sciences Training Grant
- Duke University Program in Environmental Health
- Duke KURe Program
- Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Building Interdisciplinary Research Careers in Women's Health
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight
- Translational Research in Surgical Oncology
- Clarifying the role of tobacco retail outlets on maternal smoking during pregnancy and child secondhand smoke exposure
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate cancer
- Organization and Function of Cellular Structure
- Pharmacological Sciences Training Program
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Epigenomics in insulin resistance associated overactive bladder
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease
- Duke University Program in Environmental Health
- Social adversities, epigenetics, and the obesity epidemic
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES)
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES)
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer
- Immune regulated amino acid pathways in Alzheimer's Disease
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer
- Cancer Biology Training Grant
- Obesity and deregulation of imprinted genes in early life
- Epigenetic influence on the early childhood self-regulation capacities and obesity
- Ovarian Cancer Initiating Cells: Metabolic Characterization
- Gene Regulation in Recurrent Ovarian Cancers
- Disparities in cervical cancer precursors and deregulation of imprinted genes
- Nutrition, Deregulation of Imprinted Genes and Rapid Weight Gain in Early Life
- Characterizing Alcohol's Effects on Repair of Liver Injury
- Identification and Characterization of Epigenetically Labile Genes
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis
Ding, X., A. B. Mohd, Z. Huang, T. Baba, M. Q. Bernardini, H. K. Lyerly, A. Berchuck, S. K. Murphy, A. B. Buermeyer, and G. R. Devi. “MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.” Br J Cancer 101, no. 2 (July 21, 2009): 269–77. https://doi.org/10.1038/sj.bjc.6605180.
Huang, Zhiqing, Yaqing Wen, Lauren Simel, Thomas Price, Andrew Berchuck, and Susan K. Murphy. “CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer.” Cancer Research 69 (May 1, 2009).
Kondoh, Eiji, Tsukasa Baba, Noriomi Matsumura, Ikuo Konishi, Shingo Fujii, Andrew Berchuck, and Susan Murphy. “UCN-01 is effective in targeting ovarian cancer spheroids.” Cancer Research 69 (May 1, 2009).
Berchuck, Andrew, Edwin S. Iversen, Jingqin Luo, Jennifer P. Clarke, Hisani Horne, Douglas A. Levine, Jeff Boyd, et al. “Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.” Clin Cancer Res 15, no. 7 (April 1, 2009): 2448–55. https://doi.org/10.1158/1078-0432.CCR-08-2430.
Kondoh, Eiji, Takako Okamoto, Toshihiro Higuchi, Keiji Tatsumi, Tsukasa Baba, Susan K. Murphy, Kenji Takakura, Ikuo Konishi, and Shingo Fujii. “Stress affects uterine receptivity through an ovarian-independent pathway.” Hum Reprod 24, no. 4 (April 2009): 945–53. https://doi.org/10.1093/humrep/den461.
Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium.” In Reproductive Sciences, 16:216A-216A. SAGE PUBLICATIONS INC, 2009.
Murphy, Susan K., Friederike L. Jayes, Liping Feng, Zhiqing Huang, and Phyllis C. Leppert. “Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium.” In Reproductive Sciences, 16:214A-214A. SAGE PUBLICATIONS INC, 2009.
Kondoh, E., T. Baba, N. Malsumura, I. Konishi, S. Fujii, A. Berchuck, and S. K. Murphy. “7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids.” Gynecologic Oncology 112, no. 2 (February 1, 2009): S161–62.
Yamaguchi, K., M. Mandai, N. Matsumura, T. Baba, T. Oura, S. Matsui, S. K. Murphy, A. Berchuck, S. Fujii, and I. Konishi. “Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts.” Gynecologic Oncology 112, no. 2 (February 1, 2009): S132–S132.