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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Wang, W, Huper, G, Guo, Y, Murphy, SK, Olson, JA, and Marks, JR. "Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer." Oncogene 24, no. 16 (April 14, 2005): 2705-2714.

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Murphy, SK, Freking, BA, Smith, TPL, Leymaster, K, Nolan, CM, Wylie, AA, Evans, HK, and Jirtle, RL. "Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep." Mammalian Genome : Official Journal of the International Mammalian Genome Society 16, no. 3 (March 2005): 171-183.

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Weidman, JR, Murphy, SK, Nolan, CM, Dietrich, FS, and Jirtle, RL. "Phylogenetic footprint analysis of IGF2 in extant mammals." Genome Research 14, no. 9 (September 2004): 1726-1732. (Letter)

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Murphy, SK, Wylie, AA, Coveler, KJ, Cotter, PD, Papenhausen, PR, Sutton, VR, Shaffer, LG, and Jirtle, RL. "Epigenetic detection of human chromosome 14 uniparental disomy." Human Mutation 22, no. 1 (July 2003): 92-97.

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Murphy, SK, and Jirtle, RL. "Imprinting evolution and the price of silence." Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 25, no. 6 (June 2003): 577-588. (Review)

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Dietz, LG, Wylie, AA, Rauen, KA, Murphy, SK, Jirtle, RL, and Cotter, PD. "Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay." J Med Genet 40, no. 4 (April 2003): e46-. (Letter)

Scholars@Duke

Dietz, L, Wylie, AA, Rauen, KA, Murphy, SK, Jirtle, RL, and Cotter, PD. "Exclusion of maternal uniparental disomy of chromosome 14 in Prader-Willi syndrome referrals using a rapid methylation PCR assay." October 2002.

Scholars@Duke

Freking, BA, Murphy, SK, Wylie, AA, Rhodes, SJ, Keele, JW, Leymaster, KA, Jirtle, RL, and Smith, TPL. "Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals." Genome Research 12, no. 10 (October 2002): 1496-1506.

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Li, T, Vu, TH, Lee, K-O, Yang, Y, Nguyen, CV, Bui, HQ, Zeng, Z-L, Nguyen, BT, Hu, J-F, Murphy, SK, Jirtle, RL, and Hoffman, AR. "An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa." Journal of Biological Chemistry 277, no. 16 (2002): 13518-13527.

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Murphy, SK, Wylie, AA, McVie-Wylie, AJ, Pulford, D, Nolan, CM, Orton, TC, and Jirtle, RL. "Development and characterization of a conditional M6p/Igf2r knockout mouse." AMERICAN JOURNAL OF HUMAN GENETICS 69, no. 4 (October 2001): 363-363.

Scholars@Duke

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