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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Murphy, Susan K., Alison H. Gusberg, Zhiqing Huang, Lauren R. Simel, Regina S. Whitaker, and Andrew Berchuck. “Overexpression of imprinted DLK1 in epithelial ovarian cancer.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.

Scholars@Duke

Huang, Zhiqing, Alison H. Gusberg, Regina S. Whitaker, Andrew Berchuck, and Susan K. Murphy. “YY1 imprint status and role in ovarian carcinogenesis.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.

Scholars@Duke

Murphy, Susan K., Catherine M. Nolan, Zhiqing Huang, Katerina S. Kucera, Brad A. Freking, Timothy P. L. Smith, Kreg A. Leymaster, Jennifer R. Weidman, and Randy L. Jirtle. “Callipyge mutation affects gene expression in cis: a potential role for chromatin structure..” Genome Research 16, no. 3 (March 2006): 340–46. https://doi.org/10.1101/gr.4389306.

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Huang, Zhiqing, Yaqing Wen, Ruby Shandilya, Jeffrey R. Marks, Andrew Berchuck, and Susan K. Murphy. “High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer..” Nucleic Acids Res 34, no. 2 (2006): 555–63. https://doi.org/10.1093/nar/gkj468.

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Berchuck, Andrew, Edwin S. Iversen, Johnathan M. Lancaster, Jennifer Pittman, Jingqin Luo, Paula Lee, Susan Murphy, et al. “Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers..” Clin Cancer Res 11, no. 10 (May 15, 2005): 3686–96. https://doi.org/10.1158/1078-0432.CCR-04-2398.

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Spillman, Monique A., Joellen M. Schildkraut, Susan Halabi, Patricia Moorman, Brian Calingaert, Rex C. Bentley, Jeffrey R. Marks, Susan Murphy, and Andrew Berchuck. “Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk..” Gynecol Oncol 97, no. 2 (May 2005): 543–49. https://doi.org/10.1016/j.ygyno.2005.01.025.

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Wang, Wei, Gudrun Huper, Yueqi Guo, Susan K. Murphy, John A. Olson, and Jeffrey R. Marks. “Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer..” Oncogene 24, no. 16 (April 2005): 2705–14. https://doi.org/10.1038/sj.onc.1208464.

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Murphy, Susan K., Brad A. Freking, Timothy P. L. Smith, Kreg Leymaster, Catherine M. Nolan, Andrew A. Wylie, Heather K. Evans, and Randy L. Jirtle. “Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep..” Mamm Genome 16, no. 3 (March 2005): 171–83. https://doi.org/10.1007/s00335-004-2421-1.

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Schildkraut, J. M., A. Berchuck, S. Murphy, J. Marks, P. Moorman, B. Calingaert, and S. Halabi. “Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer..” In Cancer Epidemiology Biomarkers & Prevention, 13:1897S-1897S. AMER ASSOC CANCER RESEARCH, 2004.

Scholars@Duke

Weidman, Jennifer R., Susan K. Murphy, Catherine M. Nolan, Fred S. Dietrich, and Randy L. Jirtle. “Phylogenetic footprint analysis of IGF2 in extant mammals..” Genome Res 14, no. 9 (September 2004): 1726–32. https://doi.org/10.1101/gr.2774804.

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