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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease.  I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina - Charlotte, 1992

Selected Grants and Awards

Publications

Spillman, Monique A., Judith Lacy, Susan K. Murphy, Regina S. Whitaker, Lisa Grace, Vanessa Teaberry, Jeffrey R. Marks, and Andrew Berchuck. “Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.” Gynecol Oncol 105, no. 2 (May 2007): 312–20. https://doi.org/10.1016/j.ygyno.2006.12.017.

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Price, Thomas M., Susan K. Murphy, and Edward V. Younglai. “Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors.” Toxicol Sci 96, no. 2 (April 2007): 218–26. https://doi.org/10.1093/toxsci/kfl196.

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Risinger, John Ian, Gadisetti V. R. Chandramouli, G Larry Maxwell, Mary Custer, Svetlana Pack, Dmitri Loukinov, Olga Aprelikova, et al. “Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.” Clin Cancer Res 13, no. 6 (March 15, 2007): 1713–19. https://doi.org/10.1158/1078-0432.CCR-05-2569.

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Schildkraut, Joellen M., Susan K. Murphy, Rachel T. Palmieri, Edwin Iversen, Patricia G. Moorman, Zhiqing Huang, Susan Halabi, et al. “Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.” Cancer Epidemiol Biomarkers Prev 16, no. 3 (March 2007): 473–80. https://doi.org/10.1158/1055-9965.EPI-06-0868.

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Murphy, Susan K., Zhiqing Huang, Yaqing Wen, Monique A. Spillman, Regina S. Whitaker, Lauren R. Simel, Teresa D. Nichols, Jeffrey R. Marks, and Andrew Berchuck. “Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.” Mol Cancer Res 4, no. 4 (April 2006): 283–92. https://doi.org/10.1158/1541-7786.MCR-05-0138.

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Schildkraut, Joellen M., Amy French, Brian Calingaert, Rex C. Bentley, Susan Murphy, Jeffrey R. Marks, Patricia Moorman, Susan Halabi, and Andrew Berchuck. “Molecular epidemiology of cyclin E overexpression in epithelial ovarian cancer.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.

Scholars@Duke

Murphy, Susan K., Alison H. Gusberg, Zhiqing Huang, Lauren R. Simel, Regina S. Whitaker, and Andrew Berchuck. “Overexpression of imprinted DLK1 in epithelial ovarian cancer.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.

Scholars@Duke

Huang, Zhiqing, Alison H. Gusberg, Regina S. Whitaker, Andrew Berchuck, and Susan K. Murphy. “YY1 imprint status and role in ovarian carcinogenesis.” In Cancer Research, Vol. 66. AMER ASSOC CANCER RESEARCH, 2006.

Scholars@Duke

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