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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Murphy, S. K., A. A. Wylie, K. J. Coveler, P. D. Cotter, P. R. Papenhausen, V. R. Sutton, L. G. Shaffer, and R. L. Jirtle. “Epigenetic detection of human chromosome 14 uniparental disomy..” Hum Mutat 22, no. 1 (July 2003): 92–97. https://doi.org/10.1002/humu.10237.

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Dietz, L. G., A. A. Wylie, K. A. Rauen, S. K. Murphy, R. L. Jirtle, and P. D. Cotter. “Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay..” J Med Genet 40, no. 4 (April 2003). https://doi.org/10.1136/jmg.40.4.e46.

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Dietz, L., A. A. Wylie, K. A. Rauen, S. K. Murphy, R. L. Jirtle, and P. D. Cotter. “Exclusion of maternal uniparental disomy of chromosome 14 in Prader-Willi syndrome referrals using a rapid methylation PCR assay..” In American Journal of Human Genetics, 71:553–553. UNIV CHICAGO PRESS, 2002.

Scholars@Duke

Freking, Brad A., Susan K. Murphy, Andrew A. Wylie, Simon J. Rhodes, John W. Keele, Kreg A. Leymaster, Randy L. Jirtle, and Timothy P. L. Smith. “Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals..” Genome Res 12, no. 10 (October 2002): 1496–1506. https://doi.org/10.1101/gr.571002.

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Li, Tao, Thanh H. Vu, Kok-Onn Lee, Youwen Yang, Chuyen V. Nguyen, Huy Q. Bui, Zhi-Lan Zeng, et al. “An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa..” J Biol Chem 277, no. 16 (April 19, 2002): 13518–27. https://doi.org/10.1074/jbc.M200458200.

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Murphy, S. K., A. A. Wylie, A. J. McVie-Wylie, D. Pulford, C. M. Nolan, T. C. Orton, and R. L. Jirtle. “Development and characterization of a conditional M6p/Igf2r knockout mouse..” American Journal of Human Genetics 69, no. 4 (October 1, 2001): 363–363.

Scholars@Duke

Evans, H. K., A. A. Wylie, S. K. Murphy, and R. L. Jirtle. “NNATresides in a micro-imprinted domain on human chromosome 20q11.2..” American Journal of Human Genetics 69, no. 4 (October 1, 2001): 346–346.

Scholars@Duke

Evans, H. K., A. A. Wylie, S. K. Murphy, and R. L. Jirtle. “The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2..” Genomics 77, no. 1–2 (September 2001): 99–104. https://doi.org/10.1006/geno.2001.6612.

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Keller, M. A., S. K. Murphy, and G. D. Parks. “RNA replication from the simian virus 5 antigenomic promoter requires three sequence-dependent elements separated by sequence-independent spacer regions..” J Virol 75, no. 8 (April 2001): 3993–98. https://doi.org/10.1128/JVI.75.8.3993-3998.2001.

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