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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Moylan, CA, and Murphy, SK. "DNA Methylation: Basic Principles." In Medical Epigenetics, 11-31. July 1, 2016.

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Yamanoi, K, Matsumura, N, Murphy, SK, Baba, T, Abiko, K, Hamanishi, J, Yamaguchi, K, Koshiyama, M, Konishi, I, and Mandai, M. "Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer." Oncotarget 7, no. 30 (July 2016): 47620-47636.

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Schiöth, HB, Boström, A, Murphy, SK, Erhart, W, Hampe, J, Moylan, C, and Mwinyi, J. "A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease." BMC genomics 17 (June 14, 2016): 462-.

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Fuemmeler, BF, Wang, L, Iversen, ES, Maguire, R, Murphy, SK, and Hoyo, C. "Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort." Childhood obesity (Print) 12, no. 3 (June 2016): 210-218.

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Dewi, FN, Wood, CE, Willson, CJ, Register, TC, Lees, CJ, Howard, TD, Huang, Z, Murphy, SK, Tooze, JA, Chou, JW, Miller, LD, and Cline, JM. "Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques." Cancer Prevention Research (Philadelphia, Pa.) 9, no. 5 (May 2016): 385-395.

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Murakami, R, Matsumura, N, Mandai, M, Yoshihara, K, Tanabe, H, Nakai, H, Yamanoi, K, Abiko, K, Yoshioka, Y, Hamanishi, J, Yamaguchi, K, Baba, T, Koshiyama, M, Enomoto, T, Okamoto, A, Murphy, SK, Mori, S, Mikami, Y, Minamiguchi, S, and Konishi, I. "Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes." The American journal of pathology 186, no. 5 (May 2016): 1103-1113.

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Li, Y, Xie, C, Murphy, SK, Skaar, D, Nye, M, Vidal, AC, Cecil, KM, Dietrich, KN, Puga, A, Jirtle, RL, and Hoyo, C. "Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood." Environmental Health Perspectives 124, no. 5 (May 2016): 666-673.

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Joubert, BR, Felix, JF, Yousefi, P, Bakulski, KM, Just, AC, Breton, C, Reese, SE, Markunas, CA, Richmond, RC, Xu, C-J, Küpers, LK, Oh, SS, Hoyo, C, Gruzieva, O, Söderhäll, C, Salas, LA, Baïz, N, Zhang, H, Lepeule, J, Ruiz, C, Ligthart, S, Wang, T, Taylor, JA, Duijts, L, Sharp, GC, Jankipersadsing, SA, Nilsen, RM, Vaez, A, Fallin, MD, Hu, D, Litonjua, AA, Fuemmeler, BF, Huen, K, Kere, J, Kull, I, Munthe-Kaas, MC, Gehring, U, Bustamante, M, Saurel-Coubizolles, MJ, Quraishi, BM, Ren, J, Tost, J, Gonzalez, JR, Peters, MJ, Håberg, SE, Xu, Z, van Meurs, JB, Gaunt, TR, Kerkhof, M, Corpeleijn, E, Feinberg, AP, Eng, C, Baccarelli, AA, Benjamin Neelon, SE, Bradman, A, Merid, SK, Bergström, A, Herceg, Z, Hernandez-Vargas, H, Brunekreef, B, Pinart, M, Heude, B, Ewart, S, Yao, J, Lemonnier, N, Franco, OH, Wu, MC, Hofman, A, McArdle, W, Van der Vlies, P, Falahi, F, Gillman, MW, Barcellos, LF, Kumar, A, Wickman, M, Guerra, S, Charles, M-A, Holloway, J, Auffray, C, Tiemeier, HW, Smith, GD, Postma, D, Hivert, M-F, Eskenazi, B, Vrijheid, M, Arshad, H, Antó, JM, Dehghan, A, Karmaus, W, Annesi-Maesano, I, Sunyer, J, Ghantous, A, Pershagen, G, Holland, N, Murphy, SK, DeMeo, DL, Burchard, EG, Ladd-Acosta, C, Snieder, H, Nystad, W, Koppelman, GH, Relton, CL, Jaddoe, VWV, Wilcox, A, Melén, E, and London, SJ. "DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis." American Journal of Human Genetics 98, no. 4 (April 2016): 680-696.

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Peng, J, Yoshioka, Y, Mandai, M, Matsumura, N, Baba, T, Yamaguchi, K, Hamanishi, J, Kharma, B, Murakami, R, Abiko, K, Murphy, SK, and Konishi, I. "The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target." Molecular carcinogenesis 55, no. 4 (April 2016): 335-345.

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McCullough, LE, Miller, EE, Mendez, MA, Murtha, AP, Murphy, SK, and Hoyo, C. "Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains." Clinical epigenetics 8 (January 22, 2016): 8-.

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