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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Matsumura, N, Yamanoi, K, Murphy, SK, Hamanishi, J, Abiko, K, Yamaguchi, K, Baba, T, Koshiyama, M, and Konishi, I. "Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer." Clinical Cancer Research 22, no. 2 Supplement (January 15, 2016): A38-A38.

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Su, D, Wang, X, Campbell, MR, Porter, DK, Pittman, GS, Bennett, BD, Wan, M, Englert, NA, Crowl, CL, Gimple, RN, Adamski, KN, Huang, Z, Murphy, SK, and Bell, DA. "Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes." PloS one 11, no. 12 (January 2016): e0166486-.

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Fuemmeler, BF, Lee, C-T, Soubry, A, Iversen, ES, Huang, Z, Murtha, AP, Schildkraut, JM, Jirtle, RL, Murphy, SK, and Hoyo, C. "DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament." Genetics & epigenetics 8 (January 2016): 59-67.

Scholars@Duke

Nye, MD, King, KE, Darrah, TH, Maguire, R, Jima, DD, Huang, Z, Mendez, MA, Fry, RC, Jirtle, RL, Murphy, SK, and Hoyo, C. "Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort." Environmental epigenetics 2, no. 1 (January 2016).

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King, KE, Kane, JB, Scarbrough, P, Hoyo, C, and Murphy, SK. "Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example." Biodemography and social biology 62, no. 1 (January 2016): 87-104.

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Soubry, A, Guo, L, Huang, Z, Hoyo, C, Romanus, S, Price, T, and Murphy, SK. "Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study." Clinical epigenetics 8 (January 2016): 51-.

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Peng, J, Hamanishi, J, Matsumura, N, Abiko, K, Murat, K, Baba, T, Yamaguchi, K, Horikawa, N, Hosoe, Y, Murphy, SK, Konishi, I, and Mandai, M. "Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer." Cancer research 75, no. 23 (December 2015): 5034-5045.

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Sachdeva, M, Dodd, RD, Huang, Z, Grenier, C, Ma, Y, Lev, DC, Cardona, DM, Murphy, SK, and Kirsch, DG. "Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182." Cancer letters 369, no. 1 (December 2015): 202-211.

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Varadaraj, A, Patel, P, Serrao, A, Bandyopadhay, T, Lee, NY, Jazaeri, AA, Huang, Z, Murphy, SK, and Mythreye, K. "Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia." Neoplasia (New York, N.Y.) 17, no. 11 (November 2015): 826-838.

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Hemachandra, LPMP, Shin, D-H, Dier, U, Iuliano, JN, Engelberth, SA, Uusitalo, LM, Murphy, SK, and Hempel, N. "Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma." Cancer research 75, no. 22 (November 2015): 4973-4984.

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