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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Kollins, Scott, Ed Levin, Tom Price, and Susan Murphy. “Delta-9-Tetrahydrocannabinol Exposure Alters Sperm Methylation Profiles: Concurrent Results From Humans and Rats.” In Neuropsychopharmacology, 42:S642–43. NATURE PUBLISHING GROUP, 2017.

Scholars@Duke

Sharp, Gemma C., Lucas A. Salas, Claire Monnereau, Catherine Allard, Paul Yousefi, Todd M. Everson, Jon Bohlin, et al. “Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.” Hum Mol Genet 26, no. 20 (October 15, 2017): 4067–85. https://doi.org/10.1093/hmg/ddx290.

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Li, Xiaoyi, Cynthia A. Moylan, Susan S. Baker, Wensheng Liu, Robert D. Baker, Susan K. Murphy, Manal F. Abdelmalek, Ruixin Zhu, Anna Mae Diehl, and Lixin Zhu. “Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis.” In Hepatology, 66:1071A-1072A. WILEY, 2017.

Scholars@Duke

Moylan, Cynthia A., Alisha M. Mavis, Mustafa R. Bashir, David Malik, Erol Bozdogan, Stephanie Buie, Cathrine Hoyo, Anna Mae Diehl, Susan K. Murphy, and Manal F. Abdelmalek. “Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children.” In Hepatology, 66:665A-665A. WILEY, 2017.

Scholars@Duke

Murphy, S. K., R. Schrott, Z. Visco, Z. Huang, C. Grenier, J. Mitchell, J. Schechter, et al. “Environment and Gametic Epigenetic Reprogramming.” In Environmental and Molecular Mutagenesis, 58:S28–S28. WILEY, 2017.

Scholars@Duke

Cordero, Francisco J., Zhiqing Huang, Carole Grenier, Xingyao He, Guo Hu, Roger E. McLendon, Susan K. Murphy, Rintaro Hashizume, and Oren J. Becher. “Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.” Mol Cancer Res 15, no. 9 (September 2017): 1243–54. https://doi.org/10.1158/1541-7786.MCR-16-0389.

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Liu, Yongmei, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, et al. “Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.” Nat Commun 8, no. 1 (August 30, 2017): 393. https://doi.org/10.1038/s41467-017-00517-4.

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McCullough, Lauren E., Erline E. Miller, Laura E. Calderwood, Nitin Shivappa, Susan E. Steck, Michele R. Forman, Michelle A Mendez, et al. “Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?” Epigenetics 12, no. 8 (August 2017): 688–97. https://doi.org/10.1080/15592294.2017.1347241.

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Huang, Zhiqing, Brad Foster, Carole Grenier, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan K. Murphy. “Abstract 1991: Enhanced role of the extracellular matrix in ovarian cancer recurrence.” In Tumor Biology. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-7445.am2017-1991.

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Gonzalez-Nahm, Sarah, Michelle Mendez, Whitney Robinson, Susan K. Murphy, Cathrine Hoyo, Vijaya Hogan, and Diane Rowley. “Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants.” Environ Epigenet 3, no. 2 (May 2017): dvx007. https://doi.org/10.1093/eep/dvx007.

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