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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Murphy, S. K., R. Schrott, Z. Visco, Z. Huang, C. Grenier, J. Mitchell, J. Schechter, et al. “Environment and Gametic Epigenetic Reprogramming..” In Environmental and Molecular Mutagenesis, 58:S28–S28. WILEY, 2017.

Scholars@Duke

Cordero, Francisco J., Zhiqing Huang, Carole Grenier, Xingyao He, Guo Hu, Roger E. McLendon, Susan K. Murphy, Rintaro Hashizume, and Oren J. Becher. “Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG..” Mol Cancer Res 15, no. 9 (September 2017): 1243–54. https://doi.org/10.1158/1541-7786.MCR-16-0389.

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Liu, Yongmei, Lindsay M. Reynolds, Jingzhong Ding, Li Hou, Kurt Lohman, Tracey Young, Wei Cui, et al. “Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis..” Nat Commun 8, no. 1 (August 30, 2017). https://doi.org/10.1038/s41467-017-00517-4.

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McCullough, Lauren E., Erline E. Miller, Laura E. Calderwood, Nitin Shivappa, Susan E. Steck, Michele R. Forman, Michelle A Mendez, et al. “Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?.” Epigenetics 12, no. 8 (August 2017): 688–97. https://doi.org/10.1080/15592294.2017.1347241.

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Huang, Zhiqing, Brad Foster, Carole Grenier, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan K. Murphy. “Abstract 1991: Enhanced role of the extracellular matrix in ovarian cancer recurrence.” In Tumor Biology. American Association for Cancer Research, 2017. https://doi.org/10.1158/1538-7445.am2017-1991.

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Gonzalez-Nahm, Sarah, Michelle Mendez, Whitney Robinson, Susan K. Murphy, Cathrine Hoyo, Vijaya Hogan, and Diane Rowley. “Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants..” Environ Epigenet 3, no. 2 (May 2017). https://doi.org/10.1093/eep/dvx007.

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Luo, Yiwen, Lauren E. McCullough, Jung-Ying Tzeng, Thomas Darrah, Avner Vengosh, Rachel L. Maguire, Arnab Maity, et al. “Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight..” Bmc Public Health 17, no. 1 (April 24, 2017). https://doi.org/10.1186/s12889-017-4225-8.

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Moylan, Cynthia A., Ricardo Henao Giraldo, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool.” In Gastroenterology, 152:S1069–70. Elsevier BV, 2017. https://doi.org/10.1016/s0016-5085(17)33611-9.

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Breton, Carrie V., Carmen J. Marsit, Elaine Faustman, Kari Nadeau, Jaclyn M. Goodrich, Dana C. Dolinoy, Julie Herbstman, et al. “Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group..” Environ Health Perspect 125, no. 4 (April 2017): 511–26. https://doi.org/10.1289/EHP595.

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Hoffman, Kate, Craig M. Butt, Thomas F. Webster, Emma V. Preston, Stephanie C. Hammel, Colleen Makey, Amelia M. Lorenzo, et al. “Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States..” Environ Sci Technol Lett 4, no. 3 (March 14, 2017): 112–18. https://doi.org/10.1021/acs.estlett.6b00475.

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