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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Luo, Yiwen, Lauren E. McCullough, Jung-Ying Tzeng, Thomas Darrah, Avner Vengosh, Rachel L. Maguire, Arnab Maity, et al. “Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.” Bmc Public Health 17, no. 1 (April 24, 2017): 354. https://doi.org/10.1186/s12889-017-4225-8.

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Moylan, Cynthia A., Ricardo Henao Giraldo, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool.” In Gastroenterology, 152:S1069–70. Elsevier BV, 2017. https://doi.org/10.1016/s0016-5085(17)33611-9.

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Breton, Carrie V., Carmen J. Marsit, Elaine Faustman, Kari Nadeau, Jaclyn M. Goodrich, Dana C. Dolinoy, Julie Herbstman, et al. “Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.” Environ Health Perspect 125, no. 4 (April 2017): 511–26. https://doi.org/10.1289/EHP595.

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Hoffman, Kate, Craig M. Butt, Thomas F. Webster, Emma V. Preston, Stephanie C. Hammel, Colleen Makey, Amelia M. Lorenzo, et al. “Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States.” Environ Sci Technol Lett 4, no. 3 (March 14, 2017): 112–18. https://doi.org/10.1021/acs.estlett.6b00475.

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Mwinyi, Jessica, Adrian E. Boström, Claudia Pisanu, Susan K. Murphy, Wiebke Erhart, Clemens Schafmayer, Jochen Hampe, Cynthia Moylan, and Helgi B. Schiöth. “NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition.” Biochim Biophys Acta Mol Cell Biol Lipids 1862, no. 3 (March 2017): 314–23. https://doi.org/10.1016/j.bbalip.2016.12.005.

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Bradley, Megan S., Marie-Helene Boudreau, Carole Grenier, Zhiqing Huang, Susan Murphy, and Nazema Y. Siddiqui. “STANDARDIZATION OF RNA PROCESSING FROM URINE SEDIMENT IN A CLINICAL SETTING.” In Neurourology and Urodynamics, 36:S18–S18. WILEY-BLACKWELL, 2017.

Scholars@Duke

Bradley, Megan S., Emily Burke, Carole Grenier, Cindy L. Amundsen, Susan Murphy, and Nazema Y. Siddiqui. “URINARY METHYLATION PATTERNS IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME.” In Neurourology and Urodynamics, 36:S17–18. WILEY-BLACKWELL, 2017.

Scholars@Duke

Maguire, R. L., A. C. Vidal, S. K. Murphy, and C. Hoyo. “Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities?” Adv Cancer Res 133 (2017): 129–56. https://doi.org/10.1016/bs.acr.2016.09.001.

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Gao, Lu, Joshua Millstein, Kimberly D. Siegmund, Louis Dubeau, Rachel Maguire, Frank D. Gilliland, Susan K. Murphy, Cathrine Hoyo, and Carrie V. Breton. “Epigenetic regulation of AXL and risk of childhood asthma symptoms.” Clin Epigenetics 9 (2017): 121. https://doi.org/10.1186/s13148-017-0421-8.

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Soubry, Adelheid, Cathrine Hoyo, Craig M. Butt, Steffen Fieuws, Thomas M. Price, Susan K. Murphy, and Heather M. Stapleton. “Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.” Environ Epigenet 3, no. 1 (January 2017): dvx003. https://doi.org/10.1093/eep/dvx003.

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