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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Baba, T, Kang, HS, Hosoe, Y, Kharma, B, Abiko, K, Matsumura, N, Hamanishi, J, Yamaguchi, K, Yoshioka, Y, Koshiyama, M, Mandai, M, Murphy, SK, and Konishi, I. "Menstrual cyclic change of metastin/GPR54 in endometrium." Medical molecular morphology 48, no. 2 (June 2015): 76-84.

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Tang, X, Keenan, MM, Wu, J, Lin, C-A, Dubois, L, Thompson, JW, Freedland, SJ, Murphy, SK, and Chi, J-T. "Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis." PLoS genetics 11, no. 4 (April 7, 2015): e1005158-.

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Nye, MD, Hoyo, C, and Murphy, SK. "In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST." Toxicology in vitro : an international journal published in association with BIBRA 29, no. 3 (April 2015): 544-550.

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Soubry, A, Murphy, SK, Wang, F, Huang, Z, Vidal, AC, Fuemmeler, BF, Kurtzberg, J, Murtha, A, Jirtle, RL, Schildkraut, JM, and Hoyo, C. "Newborns of obese parents have altered DNA methylation patterns at imprinted genes." Int J Obes (Lond) 39, no. 4 (April 2015): 650-657.

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Mo, L, Pospichalova, V, Huang, Z, Murphy, SK, Payne, S, Wang, F, Kennedy, M, Cianciolo, GJ, Bryja, V, Pizzo, SV, and Bachelder, RE. "Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells." PloS one 10, no. 7 (January 2015): e0131579-.

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McCullough, LE, Mendez, MA, Miller, EE, Murtha, AP, Murphy, SK, and Hoyo, C. "Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort." Epigenetics 10, no. 7 (January 2015): 597-606.

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King, K, Murphy, S, and Hoyo, C. "Epigenetic regulation of Newborns' imprinted genes related to gestational growth: Patterning by parental race/ethnicity and maternal socioeconomic status." Journal of Epidemiology and Community Health (2015).

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Okamoto, T, Mandai, M, Matsumura, N, Yamaguchi, K, Kondoh, H, Amano, Y, Baba, T, Hamanishi, J, Abiko, K, Kosaka, K, Murphy, SK, Mori, S, and Konishi, I. "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma." Molecular Carcinogenesis 54, no. 1 (2015): 35-49.

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Okamoto, T, Mandai, M, Matsumura, N, Yamaguchi, K, Kondoh, H, Amano, Y, Baba, T, Hamanishi, J, Abiko, K, Kosaka, K, Murphy, SK, Mori, S, and Konishi, I. "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma." Mol Carcinog 54, no. 1 (January 2015): 35-49.

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Vidal, AC, Skaar, D, Maguire, R, Dodor, S, Musselwhite, LW, Bartlett, JA, Oneko, O, Obure, J, Mlay, P, Murphy, SK, and Hoyo, C. "IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes." Infectious agents and cancer 10 (January 2015): 10-.

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