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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Keenan, MM, Liu, B, Tang, X, Wu, J, Cyr, D, Stevens, RD, Ilkayeva, O, Huang, Z, Tollini, LA, Murphy, SK, Lucas, J, Muoio, DM, Kim, SY, and Chi, J-T. "ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate." PLoS genetics 11, no. 10 (October 9, 2015): e1005599-.

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King, KE, Darrah, TH, Money, E, Meentemeyer, R, Maguire, RL, Nye, MD, Michener, L, Murtha, AP, Jirtle, R, Murphy, SK, Mendez, MA, Robarge, W, Vengosh, A, and Hoyo, C. "Geographic clustering of elevated blood heavy metal levels in pregnant women." BMC public health 15 (October 9, 2015): 1035-.

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Ding, J, Reynolds, LM, Zeller, T, Müller, C, Lohman, K, Nicklas, BJ, Kritchevsky, SB, Huang, Z, de la Fuente, A, Soranzo, N, Settlage, RE, Chuang, C-C, Howard, T, Xu, N, Goodarzi, MO, Chen, Y-DI, Rotter, JI, Siscovick, DS, Parks, JS, Murphy, S, Jacobs, DR, Post, W, Tracy, RP, Wild, PS, Blankenberg, S, Hoeschele, I, Herrington, D, McCall, CE, and Liu, Y. "Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease." Diabetes 64, no. 10 (October 2015): 3464-3474.

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Moylan, CA, Murphy, SK, Grenier, C, Abdelmalek, MF, and Diehl, AM. "DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease." October 2015.

Scholars@Duke

Murphy, SK, Erginer, E, Huang, Z, Visco, Z, and Hoyo, C. "Genotype-Epigenotype Interaction at the IGF2 DMR." Genes 6, no. 3 (August 28, 2015): 777-789.

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Huang, Z, Visco, Z, Sfakianos, G, Whitaker, R, Berchuck, A, and Murphy, SK. "Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer." August 1, 2015.

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Vidal, AC, Semenova, V, Darrah, T, Vengosh, A, Huang, Z, King, K, Nye, MD, Fry, R, Skaar, D, Maguire, R, Murtha, A, Schildkraut, J, Murphy, S, and Hoyo, C. "Maternal cadmium, iron and zinc levels, DNA methylation and birth weight." Bmc Pharmacology & Toxicology 16 (July 15, 2015): 20-null.

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Taylor, MM, and Murphy, SK. "Systems Biology and the Epigenome." In Systems Biology in Toxicology and Environmental Health, 43-56. July 7, 2015.

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King, K, Murphy, S, and Hoyo, C. "Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status." Journal of epidemiology and community health 69, no. 7 (July 2015): 639-647.

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Baba, T, Kang, HS, Hosoe, Y, Kharma, B, Abiko, K, Matsumura, N, Hamanishi, J, Yamaguchi, K, Yoshioka, Y, Koshiyama, M, Mandai, M, Murphy, SK, and Konishi, I. "Menstrual cyclic change of metastin/GPR54 in endometrium." Medical Molecular Morphology 48, no. 2 (June 1, 2015): 76-84.

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