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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.14309/00000434-201610001-00871.

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Murphy, S. K., S. Keyhan, L. Guo, K. Tomins, M. Taylor, R. Joglekar, Z. Huang, et al. “Environmental Influence on Preconceptional and Gestational DNA Methylation Profiles.” In Environmental and Molecular Mutagenesis, 57:S39–S39. WILEY-BLACKWELL, 2016.

Scholars@Duke

Yamanoi, Koji, Noriomi Matsumura, Susan K. Murphy, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Masafumi Koshiyama, Ikuo Konishi, and Masaki Mandai. “Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.” Oncotarget 7, no. 30 (July 26, 2016): 47620–36. https://doi.org/10.18632/oncotarget.9951.

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Schiöth, Helgi B., Adrian Boström, Susan K. Murphy, Wiebke Erhart, Jochen Hampe, Cynthia Moylan, and Jessica Mwinyi. “A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.” Bmc Genomics 17 (June 14, 2016): 462. https://doi.org/10.1186/s12864-016-2814-z.

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Fuemmeler, Bernard F., Lin Wang, Edwin S. Iversen, Rachel Maguire, Susan K. Murphy, and Cathrine Hoyo. “Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort.” Child Obes 12, no. 3 (June 2016): 210–18. https://doi.org/10.1089/chi.2015.0253.

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Dewi, Fitriya N., Charles E. Wood, Cynthia J. Willson, Thomas C. Register, Cynthia J. Lees, Timothy D. Howard, Zhiqing Huang, et al. “Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.” Cancer Prev Res (Phila) 9, no. 5 (May 2016): 385–95. https://doi.org/10.1158/1940-6207.CAPR-15-0165.

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Murakami, Ryusuke, Noriomi Matsumura, Masaki Mandai, Kosuke Yoshihara, Hiroshi Tanabe, Hidekatsu Nakai, Koji Yamanoi, et al. “Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.” Am J Pathol 186, no. 5 (May 2016): 1103–13. https://doi.org/10.1016/j.ajpath.2015.12.029.

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Li, Yue, Changchun Xie, Susan K. Murphy, David Skaar, Monica Nye, Adriana C. Vidal, Kim M. Cecil, et al. “Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.” Environ Health Perspect 124, no. 5 (May 2016): 666–73. https://doi.org/10.1289/ehp.1408577.

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Joubert, Bonnie R., Janine F. Felix, Paul Yousefi, Kelly M. Bakulski, Allan C. Just, Carrie Breton, Sarah E. Reese, et al. “DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.” Am J Hum Genet 98, no. 4 (April 7, 2016): 680–96. https://doi.org/10.1016/j.ajhg.2016.02.019.

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