Nagura, M, Matsumura, N, Baba, T, Murakami, R, Kharma, B, Hamanishi, J, Yamaguchi, K, Abiko, K, Koshiyama, M, Mandai, M, Murata, T, Murphy, SK, and Konishi, I. "Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta." Gynecologic oncology 136, no. 1 (January 2015): 104-111.
Susan Kay Murphy, PhD
Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.
Education and Training
- Ph.D., Wake Forest University, 1998
- B.A., University of North Carolina at Charlotte, 1992
Selected Grants and Awards
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Building Interdisciplinary Research Careers in Women's Health
- Translational Research in Surgical Oncology
- Duke University Medical Center (DUMC) Pelvic Floor Disorders Network (PFDN) Clinical Site
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Organization and Function of Cellular Structure
- Epigenomics in insulin resistance associated overactive bladder
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca
- Immune regulated amino acid pathways in Alzheimer's Disease
- Duke KURe Program
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease
- Duke University Program in Environmental Health
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES)
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES)
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer
- Cancer Biology Training Grant
- Obesity and deregulation of imprinted genes in early life
- Epigenetic influence on early childhood self-regulation capacities and obesity
- Ovarian Cancer Initiating Cells: Metabolic Characterization
- Gene Regulation in Recurrent Ovarian Cancers
- Disparities in cervical cancer precursors and deregulation of imprinted genes
- Nutrition, Deregulation of Imprinted Genes
- Characterizing Alcohol's Effects on Repair of Liver Injury
- Identification and Characterization of Epigenetically Labile Genes
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis
Soubry, A, Murphy, SK, Wang, F, Huang, Z, Vidal, AC, Fuemmeler, BF, Kurtzberg, J, Murtha, A, Jirtle, RL, Schildkraut, JM, and Hoyo, C. "Newborns of obese parents have altered DNA methylation patterns at imprinted genes." International Journal of Obesity 39, no. 4 (January 1, 2015): 650-657.
Siddiqui, NY, DuBois, LG, St John-Williams, L, Will, TJ, Grenier, C, Burke, E, Fraser, MO, Amundsen, CL, and Murphy, SK. "Optimizing Urine Processing Protocols for Protein and Metabolite Detection." Journal of proteomics & bioinformatics 2015, no. Suppl 14 (January 2015).
Nye, MD, Hoyo, C, Wang, F, Murtha, AP, Schildkraut, JM, Kurtzberg, J, Jirtle, RL, Huang, Z, and Murphy, SK. "Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort." Cancer Epidemiology Biomarkers & Prevention 23, no. 11 Supplement (November 2014): B22-B22.
Kharma, B, Baba, T, Matsumura, N, Kang, HS, Hamanishi, J, Murakami, R, McConechy, MM, Leung, S, Yamaguchi, K, Hosoe, Y, Yoshioka, Y, Murphy, SK, Mandai, M, Hunstman, DG, and Konishi, I. "STAT1 drives tumor progression in serous papillary endometrial cancer." Cancer research 74, no. 22 (November 2014): 6519-6530.
Stevens, EV, Whitaker, R, Guinet, A, Chang, C-Y, Grenier, C, Marks, J, McDonnell, DP, Murphy, SK, Berchuck, A, and Gaillard, S. "Abstract 4570: Role of ERRalpha in ovarian cancer." October 1, 2014.
Kharma, B, Baba, T, Matsumura, N, Kang, HS, Murakami, R, Yamaguchi, K, Hamanishi, J, Mandai, M, Murphy, SK, and Konishi, I. "Abstract LB-123: Novel function of STAT1 pathway as a modulator of tumor progression in serous papillary endometrial cancer." October 1, 2014.
Yamaguchi, K, Huang, Z, Matsumura, N, Mandai, M, Okamoto, T, Baba, T, Konishi, I, Berchuck, A, and Murphy, SK. "Epigenetic determinants of ovarian clear cell carcinoma biology." International Journal of Cancer 135, no. 3 (August 1, 2014): 585-597.
Yamaguchi, K, Huang, Z, Matsumura, N, Mandai, M, Okamoto, T, Baba, T, Konishi, I, Berchuck, A, and Murphy, SK. "Epigenetic determinants of ovarian clear cell carcinoma biology." Int J Cancer 135, no. 3 (August 1, 2014): 585-597.
Hoyo, C, Daltveit, AK, Iversen, E, Benjamin-Neelon, SE, Fuemmeler, B, Schildkraut, J, Murtha, AP, Overcash, F, Vidal, AC, Wang, F, Huang, Z, Kurtzberg, J, Seewaldt, V, Forman, M, Jirtle, RL, and Murphy, SK. "Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort." Epigenetics 9, no. 8 (August 2014): 1120-1130.