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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Nye, MD, Hoyo, C, and Murphy, SK. "In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST." Toxicology in vitro : an international journal published in association with BIBRA 29, no. 3 (April 2015): 544-550.

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Soubry, A, Murphy, SK, Wang, F, Huang, Z, Vidal, AC, Fuemmeler, BF, Kurtzberg, J, Murtha, A, Jirtle, RL, Schildkraut, JM, and Hoyo, C. "Newborns of obese parents have altered DNA methylation patterns at imprinted genes." Int J Obes (Lond) 39, no. 4 (April 2015): 650-657.

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Mo, L, Pospichalova, V, Huang, Z, Murphy, SK, Payne, S, Wang, F, Kennedy, M, Cianciolo, GJ, Bryja, V, Pizzo, SV, and Bachelder, RE. "Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells." PloS one 10, no. 7 (January 2015): e0131579-.

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McCullough, LE, Mendez, MA, Miller, EE, Murtha, AP, Murphy, SK, and Hoyo, C. "Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort." Epigenetics 10, no. 7 (January 2015): 597-606.

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Okamoto, T, Mandai, M, Matsumura, N, Yamaguchi, K, Kondoh, H, Amano, Y, Baba, T, Hamanishi, J, Abiko, K, Kosaka, K, Murphy, SK, Mori, S, and Konishi, I. "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma." Molecular Carcinogenesis 54, no. 1 (2015): 35-49.

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Okamoto, T, Mandai, M, Matsumura, N, Yamaguchi, K, Kondoh, H, Amano, Y, Baba, T, Hamanishi, J, Abiko, K, Kosaka, K, Murphy, SK, Mori, S, and Konishi, I. "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma." Mol Carcinog 54, no. 1 (January 2015): 35-49.

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Vidal, AC, Skaar, D, Maguire, R, Dodor, S, Musselwhite, LW, Bartlett, JA, Oneko, O, Obure, J, Mlay, P, Murphy, SK, and Hoyo, C. "IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes." Infectious agents and cancer 10 (January 2015): 10-.

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Nagura, M, Matsumura, N, Baba, T, Murakami, R, Kharma, B, Hamanishi, J, Yamaguchi, K, Abiko, K, Koshiyama, M, Mandai, M, Murata, T, Murphy, SK, and Konishi, I. "Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta." Gynecologic oncology 136, no. 1 (January 2015): 104-111.

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Soubry, A, Murphy, SK, Wang, F, Huang, Z, Vidal, AC, Fuemmeler, BF, Kurtzberg, J, Murtha, A, Jirtle, RL, Schildkraut, JM, and Hoyo, C. "Newborns of obese parents have altered DNA methylation patterns at imprinted genes." International Journal of Obesity 39, no. 4 (January 1, 2015): 650-657.

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Nye, MD, Hoyo, C, Wang, F, Murtha, AP, Schildkraut, JM, Kurtzberg, J, Jirtle, RL, Huang, Z, and Murphy, SK. "Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort." Cancer Epidemiology Biomarkers & Prevention 23, no. 11 Supplement (November 2014): B22-B22.

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