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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Schiöth, Helgi B., Adrian Boström, Susan K. Murphy, Wiebke Erhart, Jochen Hampe, Cynthia Moylan, and Jessica Mwinyi. “A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease..” Bmc Genomics 17 (June 14, 2016). https://doi.org/10.1186/s12864-016-2814-z.

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Fuemmeler, Bernard F., Lin Wang, Edwin S. Iversen, Rachel Maguire, Susan K. Murphy, and Cathrine Hoyo. “Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort..” Child Obes 12, no. 3 (June 2016): 210–18. https://doi.org/10.1089/chi.2015.0253.

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Dewi, Fitriya N., Charles E. Wood, Cynthia J. Willson, Thomas C. Register, Cynthia J. Lees, Timothy D. Howard, Zhiqing Huang, et al. “Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques..” Cancer Prev Res (Phila) 9, no. 5 (May 2016): 385–95. https://doi.org/10.1158/1940-6207.CAPR-15-0165.

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Murakami, Ryusuke, Noriomi Matsumura, Masaki Mandai, Kosuke Yoshihara, Hiroshi Tanabe, Hidekatsu Nakai, Koji Yamanoi, et al. “Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes..” Am J Pathol 186, no. 5 (May 2016): 1103–13. https://doi.org/10.1016/j.ajpath.2015.12.029.

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Li, Yue, Changchun Xie, Susan K. Murphy, David Skaar, Monica Nye, Adriana C. Vidal, Kim M. Cecil, et al. “Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood..” Environ Health Perspect 124, no. 5 (May 2016): 666–73. https://doi.org/10.1289/ehp.1408577.

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Joubert, Bonnie R., Janine F. Felix, Paul Yousefi, Kelly M. Bakulski, Allan C. Just, Carrie Breton, Sarah E. Reese, et al. “DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis..” Am J Hum Genet 98, no. 4 (April 7, 2016): 680–96. https://doi.org/10.1016/j.ajhg.2016.02.019.

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Peng, Jin, Yumiko Yoshioka, Masaki Mandai, Noriomi Matsumura, Tsukasa Baba, Ken Yamaguchi, Junzo Hamanishi, et al. “The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target..” Mol Carcinog 55, no. 4 (April 2016): 335–45. https://doi.org/10.1002/mc.22283.

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Matsumura, Noriomi, Koji Yamanoi, Susan K. Murphy, Junzo Hamanishi, Kaoru Abiko, Ken Yamaguchi, Tsukasa Baba, Masafumi Koshiyama, and Ikuo Konishi. “Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer..” Molecular Drivers of Ovarian Cancer (Other Than P53), January 15, 2016. https://doi.org/10.1158/1557-3265.ovca15-a38.

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Horikawa, Naoki, Kaoru Abiko, Noriomi Matsumura, Junzo Hamanishi, Susan Murphy, Tsukasa Baba, Ken Yamaguchi, Masafumi Koshiyama, and Ikuo Konishi. “Abstract B63: Expression of VEGF in ovarian cancer suppresses tumor immunity through recruitment of myeloid derived suppressor cells..” In Ovarian Cancer Tumor Microenvironment. American Association for Cancer Research, 2016. https://doi.org/10.1158/1557-3265.ovca15-b63.

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Su, Dan, Xuting Wang, Michelle R. Campbell, Devin K. Porter, Gary S. Pittman, Brian D. Bennett, Ma Wan, et al. “Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes..” Plos One 11, no. 12 (2016). https://doi.org/10.1371/journal.pone.0166486.

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