Peng, Jin, Yumiko Yoshioka, Masaki Mandai, Noriomi Matsumura, Tsukasa Baba, Ken Yamaguchi, Junzo Hamanishi, et al. “The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.” Mol Carcinog 55, no. 4 (April 2016): 335–45. https://doi.org/10.1002/mc.22283.
Susan Kay Murphy, PhD
Associate Professor in Obstetrics and Gynecology
Campus Mail:
701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone:
(919) 681-3423
Email:
susan.murphy@duke.edu
Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.
Education and Training
- Ph.D., Wake Forest University, 1998
- B.A., University of North Carolina at Charlotte, 1992
Research
Selected Grants and Awards
- Population Health Research Support IDIQ Base
- Duke University Program in Environmental Health
- Duke KURe Program
- Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes?
- Building Interdisciplinary Research Careers in Women's Health
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight
- Translational Research in Surgical Oncology
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Organization and Function of Cellular Structure
- Pharmacological Sciences Training Program
- Epigenomics in insulin resistance associated overactive bladder
- Clarifying the role of tobacco retail outlets on maternal smoking during pregnancy and child secondhand smoke exposure
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease
- Duke University Program in Environmental Health
- Social adversities, epigenetics, and the obesity epidemic
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES)
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES)
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer
- Immune regulated amino acid pathways in Alzheimer's Disease
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer
- Cancer Biology Training Grant
- Obesity and deregulation of imprinted genes in early life
- Epigenetic influence on early childhood self-regulation capacities and obesity
- Ovarian Cancer Initiating Cells: Metabolic Characterization
- Gene Regulation in Recurrent Ovarian Cancers
- Disparities in cervical cancer precursors and deregulation of imprinted genes
- Nutrition, Deregulation of Imprinted Genes
- Characterizing Alcohol's Effects on Repair of Liver Injury
- Identification and Characterization of Epigenetically Labile Genes
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis
Publications
Matsumura, Noriomi, Koji Yamanoi, Susan K. Murphy, Junzo Hamanishi, Kaoru Abiko, Ken Yamaguchi, Tsukasa Baba, Masafumi Koshiyama, and Ikuo Konishi. “Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer.” Molecular Drivers of Ovarian Cancer (Other Than P53), January 15, 2016. https://doi.org/10.1158/1557-3265.ovca15-a38.
Horikawa, Naoki, Kaoru Abiko, Noriomi Matsumura, Junzo Hamanishi, Susan Murphy, Tsukasa Baba, Ken Yamaguchi, Masafumi Koshiyama, and Ikuo Konishi. “Abstract B63: Expression of VEGF in ovarian cancer suppresses tumor immunity through recruitment of myeloid derived suppressor cells.” In Ovarian Cancer Tumor Microenvironment. American Association for Cancer Research, 2016. https://doi.org/10.1158/1557-3265.ovca15-b63.
Su, Dan, Xuting Wang, Michelle R. Campbell, Devin K. Porter, Gary S. Pittman, Brian D. Bennett, Ma Wan, et al. “Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.” Plos One 11, no. 12 (2016): e0166486. https://doi.org/10.1371/journal.pone.0166486.
Fuemmeler, Bernard F., Chien-Ti Lee, Adelheid Soubry, Edwin S. Iversen, Zhiqing Huang, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.” Genet Epigenet 8 (2016): 59–67. https://doi.org/10.4137/GEG.S40538.
McCullough, Lauren E., Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy, and Cathrine Hoyo. “Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains.” Clin Epigenetics 8 (2016): 8. https://doi.org/10.1186/s13148-016-0174-9.
Nye, Monica D., Katherine E. King, Thomas H. Darrah, Rachel Maguire, Dereje D. Jima, Zhiqing Huang, Michelle A. Mendez, et al. “Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort.” Environ Epigenet 2, no. 1 (2016). https://doi.org/10.1093/eep/dvv009.
King, Katherine E., Jennifer B. Kane, Peter Scarbrough, Cathrine Hoyo, and Susan K. Murphy. “Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example.” Biodemography Soc Biol 62, no. 1 (2016): 87–104. https://doi.org/10.1080/19485565.2015.1126501.
Soubry, Adelheid, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price, and Susan K. Murphy. “Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.” Clin Epigenetics 8 (2016): 51. https://doi.org/10.1186/s13148-016-0217-2.
Peng, Jin, Junzo Hamanishi, Noriomi Matsumura, Kaoru Abiko, Kumuruz Murat, Tsukasa Baba, Ken Yamaguchi, et al. “Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.” Cancer Res 75, no. 23 (December 1, 2015): 5034–45. https://doi.org/10.1158/0008-5472.CAN-14-3098.