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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Fuemmeler, Bernard F., Chien-Ti Lee, Adelheid Soubry, Edwin S. Iversen, Zhiqing Huang, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament..” Genet Epigenet 8 (2016): 59–67. https://doi.org/10.4137/GEG.S40538.

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McCullough, Lauren E., Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy, and Cathrine Hoyo. “Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains..” Clin Epigenetics 8 (2016). https://doi.org/10.1186/s13148-016-0174-9.

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Nye, Monica D., Katherine E. King, Thomas H. Darrah, Rachel Maguire, Dereje D. Jima, Zhiqing Huang, Michelle A. Mendez, et al. “Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort..” Environ Epigenet 2, no. 1 (2016). https://doi.org/10.1093/eep/dvv009.

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King, Katherine E., Jennifer B. Kane, Peter Scarbrough, Cathrine Hoyo, and Susan K. Murphy. “Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example..” Biodemography Soc Biol 62, no. 1 (2016): 87–104. https://doi.org/10.1080/19485565.2015.1126501.

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Soubry, Adelheid, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price, and Susan K. Murphy. “Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study..” Clin Epigenetics 8 (2016). https://doi.org/10.1186/s13148-016-0217-2.

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Peng, Jin, Junzo Hamanishi, Noriomi Matsumura, Kaoru Abiko, Kumuruz Murat, Tsukasa Baba, Ken Yamaguchi, et al. “Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer..” Cancer Res 75, no. 23 (December 1, 2015): 5034–45. https://doi.org/10.1158/0008-5472.CAN-14-3098.

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Sachdeva, Mohit, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy, and David G. Kirsch. “Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182..” Cancer Lett 369, no. 1 (December 1, 2015): 202–11. https://doi.org/10.1016/j.canlet.2015.08.016.

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Hemachandra, LP Madhubhani P., Dong-Hui Shin, Usawadee Dier, James N. Iuliano, Sarah A. Engelberth, Larissa M. Uusitalo, Susan K. Murphy, and Nadine Hempel. “Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma..” Cancer Res 75, no. 22 (November 15, 2015): 4973–84. https://doi.org/10.1158/0008-5472.CAN-14-3799.

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Varadaraj, Archana, Pratik Patel, Anne Serrao, Tirthankar Bandyopadhay, Nam Y. Lee, Amir A. Jazaeri, Zhiqing Huang, Susan K. Murphy, and Karthikeyan Mythreye. “Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia..” Neoplasia 17, no. 11 (November 2015): 826–38. https://doi.org/10.1016/j.neo.2015.11.003.

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King, Katherine E., Thomas H. Darrah, Eric Money, Ross Meentemeyer, Rachel L. Maguire, Monica D. Nye, Lloyd Michener, et al. “Geographic clustering of elevated blood heavy metal levels in pregnant women..” Bmc Public Health 15 (October 9, 2015). https://doi.org/10.1186/s12889-015-2379-9.

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