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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Peng, Jin, Yumiko Yoshioka, Masaki Mandai, Noriomi Matsumura, Tsukasa Baba, Ken Yamaguchi, Junzo Hamanishi, et al. “The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.” Mol Carcinog 55, no. 4 (April 2016): 335–45. https://doi.org/10.1002/mc.22283.

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Matsumura, Noriomi, Koji Yamanoi, Susan K. Murphy, Junzo Hamanishi, Kaoru Abiko, Ken Yamaguchi, Tsukasa Baba, Masafumi Koshiyama, and Ikuo Konishi. “Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer.” Molecular Drivers of Ovarian Cancer (Other Than P53), January 15, 2016. https://doi.org/10.1158/1557-3265.ovca15-a38.

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Horikawa, Naoki, Kaoru Abiko, Noriomi Matsumura, Junzo Hamanishi, Susan Murphy, Tsukasa Baba, Ken Yamaguchi, Masafumi Koshiyama, and Ikuo Konishi. “Abstract B63: Expression of VEGF in ovarian cancer suppresses tumor immunity through recruitment of myeloid derived suppressor cells.” In Ovarian Cancer Tumor Microenvironment. American Association for Cancer Research, 2016. https://doi.org/10.1158/1557-3265.ovca15-b63.

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Su, Dan, Xuting Wang, Michelle R. Campbell, Devin K. Porter, Gary S. Pittman, Brian D. Bennett, Ma Wan, et al. “Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.” Plos One 11, no. 12 (2016): e0166486. https://doi.org/10.1371/journal.pone.0166486.

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Fuemmeler, Bernard F., Chien-Ti Lee, Adelheid Soubry, Edwin S. Iversen, Zhiqing Huang, Amy P. Murtha, Joellen M. Schildkraut, Randy L. Jirtle, Susan K. Murphy, and Cathrine Hoyo. “DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.” Genet Epigenet 8 (2016): 59–67. https://doi.org/10.4137/GEG.S40538.

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McCullough, Lauren E., Erline E. Miller, Michelle A. Mendez, Amy P. Murtha, Susan K. Murphy, and Cathrine Hoyo. “Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains.” Clin Epigenetics 8 (2016): 8. https://doi.org/10.1186/s13148-016-0174-9.

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Nye, Monica D., Katherine E. King, Thomas H. Darrah, Rachel Maguire, Dereje D. Jima, Zhiqing Huang, Michelle A. Mendez, et al. “Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort.” Environ Epigenet 2, no. 1 (2016). https://doi.org/10.1093/eep/dvv009.

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King, Katherine E., Jennifer B. Kane, Peter Scarbrough, Cathrine Hoyo, and Susan K. Murphy. “Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example.” Biodemography Soc Biol 62, no. 1 (2016): 87–104. https://doi.org/10.1080/19485565.2015.1126501.

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Soubry, Adelheid, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price, and Susan K. Murphy. “Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.” Clin Epigenetics 8 (2016): 51. https://doi.org/10.1186/s13148-016-0217-2.

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Peng, Jin, Junzo Hamanishi, Noriomi Matsumura, Kaoru Abiko, Kumuruz Murat, Tsukasa Baba, Ken Yamaguchi, et al. “Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.” Cancer Res 75, no. 23 (December 1, 2015): 5034–45. https://doi.org/10.1158/0008-5472.CAN-14-3098.

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