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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate..” Plos Genet 11, no. 10 (October 2015). https://doi.org/10.1371/journal.pgen.1005599.

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Ding, Jingzhong, Lindsay M. Reynolds, Tanja Zeller, Christian Müller, Kurt Lohman, Barbara J. Nicklas, Stephen B. Kritchevsky, et al. “Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease..” Diabetes 64, no. 10 (October 2015): 3464–74. https://doi.org/10.2337/db14-1314.

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Moylan, Cynthia A., Susan K. Murphy, Carole Grenier, Manal F. Abdelmalek, and Anna Mae Diehl. “DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:648A-649A. WILEY-BLACKWELL, 2015.

Scholars@Duke

Murphy, Susan K., Erin Erginer, Zhiqing Huang, Zachary Visco, and Cathrine Hoyo. “Genotype-Epigenotype Interaction at the IGF2 DMR..” Genes (Basel) 6, no. 3 (August 28, 2015): 777–89. https://doi.org/10.3390/genes6030777.

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Huang, Zhiqing, Zachery Visco, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan Murphy. “Abstract POSTER-BIOL-1319: Temporal shifts in the epigenetic regulation of tight junctions from primary to recurrent ovarian cancer.” In Biology of Ovarian Cancer. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1319.

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Huang, Zhiqing, Zachery Visco, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan K. Murphy. “Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-2236.

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Varadaraj, Archana, Pratik Patel, Anne Serrao, Tirthankar Bandyopadhyay, Nam Y. Lee, Amir Jazaeri, Susan Murphy, and Karthikeyan Mythreye. “Abstract 3912: GDF2 promotes anoikis susceptibility in ovarian and breast epithelia.” In Molecular and Cellular Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-3912.

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Vidal, Adriana C., Viktoriya Semenova, Thomas Darrah, Avner Vengosh, Zhiqing Huang, Katherine King, Monica D. Nye, et al. “Maternal cadmium, iron and zinc levels, DNA methylation and birth weight..” Bmc Pharmacol Toxicol 16 (July 15, 2015). https://doi.org/10.1186/s40360-015-0020-2.

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King, Katherine, Susan Murphy, and Cathrine Hoyo. “Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status..” J Epidemiol Community Health 69, no. 7 (July 2015): 639–47. https://doi.org/10.1136/jech-2014-204781.

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