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Susan Kay Murphy, PhD

Murphy
Associate Professor in Obstetrics and Gynecology
Campus Mail: 701 W. Main Street, Suite 510, Room 5140, Durham, NC 27701
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Sachdeva, Mohit, Rebecca D. Dodd, Zhiqing Huang, Carole Grenier, Yan Ma, Dina C. Lev, Diana M. Cardona, Susan K. Murphy, and David G. Kirsch. “Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.” Cancer Lett 369, no. 1 (December 1, 2015): 202–11. https://doi.org/10.1016/j.canlet.2015.08.016.

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Hemachandra, LP Madhubhani P., Dong-Hui Shin, Usawadee Dier, James N. Iuliano, Sarah A. Engelberth, Larissa M. Uusitalo, Susan K. Murphy, and Nadine Hempel. “Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma.” Cancer Res 75, no. 22 (November 15, 2015): 4973–84. https://doi.org/10.1158/0008-5472.CAN-14-3799.

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Varadaraj, Archana, Pratik Patel, Anne Serrao, Tirthankar Bandyopadhay, Nam Y. Lee, Amir A. Jazaeri, Zhiqing Huang, Susan K. Murphy, and Karthikeyan Mythreye. “Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.” Neoplasia 17, no. 11 (November 2015): 826–38. https://doi.org/10.1016/j.neo.2015.11.003.

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King, Katherine E., Thomas H. Darrah, Eric Money, Ross Meentemeyer, Rachel L. Maguire, Monica D. Nye, Lloyd Michener, et al. “Geographic clustering of elevated blood heavy metal levels in pregnant women.” Bmc Public Health 15 (October 9, 2015): 1035. https://doi.org/10.1186/s12889-015-2379-9.

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Keenan, Melissa M., Beiyu Liu, Xiaohu Tang, Jianli Wu, Derek Cyr, Robert D. Stevens, Olga Ilkayeva, et al. “ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.” Plos Genet 11, no. 10 (October 2015): e1005599. https://doi.org/10.1371/journal.pgen.1005599.

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Ding, Jingzhong, Lindsay M. Reynolds, Tanja Zeller, Christian Müller, Kurt Lohman, Barbara J. Nicklas, Stephen B. Kritchevsky, et al. “Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.” Diabetes 64, no. 10 (October 2015): 3464–74. https://doi.org/10.2337/db14-1314.

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Moylan, Cynthia A., Susan K. Murphy, Carole Grenier, Manal F. Abdelmalek, and Anna Mae Diehl. “DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:648A-649A. WILEY-BLACKWELL, 2015.

Scholars@Duke

Murphy, Susan K., Erin Erginer, Zhiqing Huang, Zachary Visco, and Cathrine Hoyo. “Genotype-Epigenotype Interaction at the IGF2 DMR.” Genes (Basel) 6, no. 3 (August 28, 2015): 777–89. https://doi.org/10.3390/genes6030777.

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Huang, Zhiqing, Zachery Visco, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan Murphy. “Abstract POSTER-BIOL-1319: Temporal shifts in the epigenetic regulation of tight junctions from primary to recurrent ovarian cancer.” In Biology of Ovarian Cancer. American Association for Cancer Research, 2015. https://doi.org/10.1158/1557-3265.ovcasymp14-poster-biol-1319.

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Huang, Zhiqing, Zachery Visco, Gregory Sfakianos, Regina Whitaker, Andrew Berchuck, and Susan K. Murphy. “Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer.” In Tumor Biology. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-2236.

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