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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Baba, Tsukasa, Hyun Sook Kang, Yuko Hosoe, Budiman Kharma, Kaoru Abiko, Noriomi Matsumura, Junzo Hamanishi, et al. “Menstrual cyclic change of metastin/GPR54 in endometrium..” Med Mol Morphol 48, no. 2 (June 2015): 76–84. https://doi.org/10.1007/s00795-014-0081-0.

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Tang, Xiaohu, Melissa M. Keenan, Jianli Wu, Chih-An Lin, Laura Dubois, J Will Thompson, Stephen J. Freedland, Susan K. Murphy, and Jen-Tsan Chi. “Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis..” Plos Genet 11, no. 4 (April 2015). https://doi.org/10.1371/journal.pgen.1005158.

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Mendez, Michelle, Shannon Grabich, Sarah Nahm, Susan Murphy, and Cathrine Hoyo. “Diet during pregnancy and disparities in fetal growth: the NEST cohort.” In Faseb Journal, Vol. 29. FEDERATION AMER SOC EXP BIOL, 2015.

Scholars@Duke

Cobb, L. P., R. Whitaker, A. Hall, G. Broadwater, S. K. Murphy, A. Berchuck, and S. Gaillard. “Evaluation of ERRα expression and association with survival in advanced ovarian cancer.” In Gynecologic Oncology, 137:204–204. Elsevier BV, 2015. https://doi.org/10.1016/j.ygyno.2015.01.513.

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Soubry, A., S. K. Murphy, F. Wang, Z. Huang, A. C. Vidal, B. F. Fuemmeler, J. Kurtzberg, et al. “Newborns of obese parents have altered DNA methylation patterns at imprinted genes..” Int J Obes (Lond) 39, no. 4 (April 2015): 650–57. https://doi.org/10.1038/ijo.2013.193.

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Mo, Lihong, Vendula Pospichalova, Zhiqing Huang, Susan K. Murphy, Sturgis Payne, Fang Wang, Margaret Kennedy, et al. “Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells..” Plos One 10, no. 7 (2015). https://doi.org/10.1371/journal.pone.0131579.

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McCullough, Lauren E., Michelle A. Mendez, Erline E. Miller, Amy P. Murtha, Susan K. Murphy, and Cathrine Hoyo. “Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort..” Epigenetics 10, no. 7 (2015): 597–606. https://doi.org/10.1080/15592294.2015.1045181.

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Okamoto, Takako, Masaki Mandai, Noriomi Matsumura, Ken Yamaguchi, Hiroshi Kondoh, Yasuaki Amano, Tsukasa Baba, et al. “Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma..” Mol Carcinog 54, no. 1 (January 2015): 35–49. https://doi.org/10.1002/mc.22072.

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Vidal, Adriana C., David Skaar, Rachel Maguire, Seyram Dodor, Laura W. Musselwhite, John A. Bartlett, Olola Oneko, et al. “IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes..” Infect Agent Cancer 10 (2015). https://doi.org/10.1186/s13027-015-0005-1.

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