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Susan Kay Murphy, PhD

Property title
Associate Professor in Obstetrics and Gynecology
Campus Mail: 226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Phone: (919) 681-3423
Email: susan.murphy@duke.edu

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Education and Training

  • Ph.D., Wake Forest University, 1998
  • B.A., University of North Carolina at Charlotte, 1992

Selected Grants and Awards

Publications

Vidal, AC, Benjamin Neelon, SE, Liu, Y, Tuli, AM, Fuemmeler, BF, Hoyo, C, Murtha, AP, Huang, Z, Schildkraut, J, Overcash, F, Kurtzberg, J, Jirtle, RL, Iversen, ES, and Murphy, SK. "Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans." Genetics & epigenetics 6 (January 2014): 37-44.

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Murphy, SK. "Obesity: Paternal obesity - A risk factor for autism?." Nature Reviews Endocrinology 10, no. 7 (January 1, 2014): 389-390.

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Vidal, AC, Henry, NM, Murphy, SK, Oneko, O, Nye, M, Bartlett, JA, Overcash, F, Huang, Z, Wang, F, Mlay, P, Obure, J, Smith, J, Vasquez, B, Swai, B, Hernandez, B, and Hoyo, C. "PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer." Clinical and Translational Oncology 16, no. 3 (2014): 266-272.

Scholars@Duke

Susan K. Murphy, CH. "What are the Implications of Distinct HPV Genotypes in Women of Different Ethnic/Racial Ancestry?." Journal of Vaccines & Vaccination 05, no. 03 (2014).

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Murphy, SK, Yang, H, Moylan, CA, Pang, H, Dellinger, A, Abdelmalek, MF, Garrett, ME, Ashley-Koch, A, Suzuki, A, Tillmann, HL, Hauser, MA, and Diehl, AM. "Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease." Gastroenterology 145, no. 5 (November 2013): 1076-1087.

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Hamanishi, J, Matsumura, N, Jin, P, Abiko, K, Horikawa, N, Yamaguchi, K, Baba, T, Murphy, SK, Konishi, I, and Mandai, M. "Abstract A83: Induction of PD-L1 expression by cytotoxic agents through activation of NF-kB signal." Clinical Cancer Research 19, no. 19 Supplement (October 1, 2013): A83-A83.

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Matsumura, N, Yamanoi, K, Amano, Y, Hamanishi, J, Baba, T, Murphy, SK, and Konishi, I. "Abstract B19: Functional genomics approach links anchorage-independence with tumor dormancy in ovarian cancer." Clinical Cancer Research 19, no. 19 Supplement (October 1, 2013): B19-B19.

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Amano, Y, Yamaguchi, K, Mandai, M, Matsumura, N, Hamanishi, J, Baba, T, Yamanoi, K, Murphy, SK, and Konishi, I. "Abstract PR08: HNF1β confers resistance to oxidative stress of ovarian clear cell carcinoma." Clinical Cancer Research 19, no. 19 Supplement (October 1, 2013): PR08-PR08.

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Vidal, AC, Murphy, SK, Murtha, AP, Schildkraut, JM, Soubry, A, Huang, Z, Neelon, SEB, Fuemmeler, B, Iversen, E, Wang, F, Kurtzberg, J, Jirtle, RL, and Hoyo, C. "Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring." Int J Obes (Lond) 37, no. 7 (July 2013): 907-913.

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Liu, Y, Hoyo, C, Murphy, S, Huang, Z, Overcash, F, Thompson, J, Brown, H, and Murtha, AP. "DNA methylation at imprint regulatory regions in preterm birth and infection." Am J Obstet Gynecol 208, no. 5 (May 2013): 395.e1-395.e7.

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