Soubry, A, Guo, L, Huang, Z, Hoyo, C, Romanus, S, Price, T, and Murphy, SK. "Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study." Clinical Epigenetics 8 (January 2016): 51-null.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Steward, RG, Zhang, CE, Shah, AA, Yeh, JS, Chen, C, Li, YJ, Price, TM, and Muasher, SJ. "High peak estradiol predicts higher miscarriage and lower live birth rates in high responders triggered with a gnrh agonist in IVF/ICSI cycles." Journal of Reproductive Medicine 60, no. 6 (December 1, 2015): 463-470.
Steward, RG, Zhang, CE, Shah, AA, Yeh, JS, Chen, C, Li, Y-J, Price, TM, and Muasher, SJ. "High Peak Estradiol Predicts Higher Miscarriage and Lower Live Birth Rates in High Responders Triggered with a GnRH Agonist in IVF/ICSI Cycles." The Journal of reproductive medicine 60, no. 11-12 (November 2015): 463-470.
Abdelmagied, A, Vaughan, L, Weaver, A, Laughlin-Tommaso, S, Hesley, G, Woodrum, D, Jacoby, V, Price, T, and Stewart, E. "Analysis of interventional fibroid therapies using a comprehensive cohort." September 2015.
Yeh, J, Daubert, M, Kuchibhatla, M, Stanczyk, F, and Price, T. "The effect of postpartum progestogen on cardiac function, NT-ProBNP, and inflammatory biomarkers in women with gestational hypertension." September 2015.
Barnhart, K, Nakajima, S, Puscheck, E, Price, T, Baker, V, and Segars, J. "Who are we? The 2014 SREI work force study." September 2015.
Price, TM, and Dai, Q. "The Role of a Mitochondrial Progesterone Receptor (PR-M) in Progesterone Action." Seminars in Reproductive Medicine 33, no. 3 (May 2015): 185-194. (Review)
Keyhan, S, Hughes, C, Price, T, and Muasher, S. "An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women." BioMed research international 2015 (January 2015): 204792-. (Review)
Tantibhedhyangkul, J, Hawkins, KC, Dai, Q, Mu, K, Dunn, CN, Miller, SE, and Price, TM. "Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential." Andrology 2, no. 6 (November 2014): 875-883.
Steward, R, Stanczyk, F, and Price, T. "The effect of depot-medroxyprogesterone acetate on resting metabolic rate in premenopausal women." September 2014.