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Thomas Michael Price, MD

Thomas Price, MD
Professor of Obstetrics and Gynecology
Campus Mail: 236 Sands Bldg, Durham, NC 27710
Phone: (919) 684-4673
Email: thomas.m.price@duke.edu

Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Education and Training

  • REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
  • Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
  • M.D., University of North Carolina at Chapel Hill, 1984

Certifications

  • American Board of Obstetrics and Gynecology, 1992
  • American Board of Reproductive Endocrinology and Infertility, 1994

Research

Dr. Price has been  involved in basic science and clinical research since completing training in 1991.  His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor. 

His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

 Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD.  I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.  

Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery. 

View Publications

Publications

Price, TM, Allen, TC, Bowyer, DL, and Watson, TA. "Ablation of luteal phase symptoms of Menière's disease with leuprolide." Arch Otolaryngol Head Neck Surg 120, no. 2 (February 1994): 209-211.

Scholars@Duke

Bulun, SE, Price, TM, Aitken, J, Mahendroo, MS, and Simpson, ER. "Erratum: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription (Journal of Clinical Endocrinology and Metabolism (1993) 77 (1622-1628))." Journal of Clinical Endocrinology and Metabolism 78, no. 2 (1994): 494--.

Scholars@Duke

Bulun, SE, Price, TM, Aitken, J, Mahendroo, MS, and Simpson, ER. "A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription." J Clin Endocrinol Metab 77, no. 6 (December 1993): 1622-1628.

Full Text

Price, TM, and O'Brien, SN. "Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification." J Clin Endocrinol Metab 77, no. 4 (October 1993): 1041-1045.

Full Text

Price, TM, Dupuis, RE, Carr, BR, Stanczyk, FZ, Lobo, RA, and Droegemueller, W. "Single- and multiple-dose pharmacokinetics of a low-dose oral contraceptive in women with chronic renal failure undergoing peritoneal dialysis." Am J Obstet Gynecol 168, no. 5 (May 1993): 1400-1406.

Scholars@Duke

Price, T, Aitken, J, Head, J, Mahendroo, M, Means, G, and Simpson, E. "Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification." The Journal of clinical endocrinology and metabolism 74, no. 6 (June 1992): 1247-1252.

Full Text

Rainey, WE, Price, TM, Means, GD, and Carr, BR. "Effect of type 1 transforming growth factor-beta on the level of aromatase cytochrome P-450 in human fetal hepatocytes." J Endocrinol 133, no. 2 (May 1992): 311-320.

Scholars@Duke

Price, T, Aitken, J, and Simpson, ER. "Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification." The Journal of clinical endocrinology and metabolism 74, no. 4 (April 1992): 879-883.

Full Text

Price, T, Aitken, J, Head, J, Mahendroo, M, Means, G, and Simpson, E. "Determination of aromatase cytochrome P450 messenger ribonucleic acid in human breast tissue by competitive polymerase chain reaction amplification." Journal of Clinical Endocrinology and Metabolism 74, no. 6 (1992): 1247-1252.

Full Text

Price, T, Aitken, J, and Simpson, ER. "Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction amplification." Journal of Clinical Endocrinology and Metabolism 74, no. 4 (1992): 879-883.

Full Text

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