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Thomas Michael Price, MD

Thomas Price, MD
Professor of Obstetrics and Gynecology
Campus Mail: 236 Sands Bldg, Durham, NC 27710
Phone: (919) 684-4673
Email: thomas.m.price@duke.edu

Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Education and Training

  • REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
  • Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
  • M.D., University of North Carolina at Chapel Hill, 1984

Certifications

  • American Board of Obstetrics and Gynecology, 1992
  • American Board of Reproductive Endocrinology and Infertility, 1994

Research

Dr. Price has been  involved in basic science and clinical research since completing training in 1991.  His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor. 

His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

 Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD.  I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.  

Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery. 

View Publications

Publications

Steward, RG, Lan, L, Shah, AA, Yeh, JS, Price, TM, Goldfarb, JM, and Muasher, SJ. "Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256,381 in vitro fertilization cycles." Fertility and Sterility 101, no. 4 (April 2014): 967-973.

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Feng, Q, Crochet, JR, Dai, Q, Leppert, PC, and Price, TM. "Expression of a mitochondrial progesterone receptor (PR-M) in leiomyomata and association with increased mitochondrial membrane potential." The Journal of Clinical Endocrinology and Metabolism 99, no. 3 (March 2014): E390-E399.

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Steward, RG, Lan, L, Shah, AA, Yeh, JS, Price, TM, Goldfarb, JM, and Muasher, SJ. "Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: An analysis of 256,381 in vitro fertilization cycles." Fertility and Sterility 101, no. 4 (January 1, 2014): 967-973.

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Shah, A, Fang, L, Leon, J, Steward, R, Price, T, and Myers, E. "Gender and infertility status affect stated preferences for outcomes of IVF." September 2013.

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Steward, R, Zhang, C, Chen, C, Li, Y-J, Price, T, and Muasher, S. "High peak estradiol (E2) predicts higher miscarriage (MC) and lower live birth (LB) rates in high-responders triggered with a gonadotropin releasing hormone agonist (GnRHa) in IVF/ICSI cycles." September 2013.

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Steward, R, Sandoval-Leon, J, Chen, C, Li, Y-J, Price, T, and Muasher, S. "High peak estradiol (E2)/mature oocyte ratio predicts lower pregnancy and live birth rates in gonadotropin releasing hormone (GnRH) antagonist/ICSI cycles." September 2013.

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Dai, Q, Shah, AA, Garde, RV, Yonish, BA, Zhang, L, Medvitz, NA, Miller, SE, Hansen, EL, Dunn, CN, and Price, TM. "A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration." Molecular Endocrinology (Baltimore, Md.) 27, no. 5 (May 2013): 741-753.

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Price, T. "Progesterone receptor membrane component 1." Menopause: The Journal of The North American Menopause Society (March 2013): 1-1.

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Price, T. "Progesterone receptor membrane component 1: Is metabolism integral to its function and what other steroids are involved?." Menopause 20, no. 5 (2013): 486-487.

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Crochet, JR, Shah, AA, Schomberg, DW, and Price, TM. "Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells." J Clin Endocrinol Metab 97, no. 9 (September 2012): E1741-E1744.

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