Dotters-Katz, S, Kuller, J, and Price, T. "The impact of familial Mediterranean fever on women's health." Obstetrical & Gynecological Survey 67, no. 6 (June 2012): 357-364. (Review)
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Steward, RG, Saleh, OA, James, AH, Shah, AA, and Price, TM. "Management of gynecologic surgery in the patient with factor XI deficiency: a review of the literature." Obstet Gynecol Surv 67, no. 5 (May 2012): 291-297. (Review)
Crochet, JR, Peavey, MC, Price, TM, and Behera, MA. "Spontaneous pregnancy reaches viability after low first trimester serum progesterone: a case report." J Reprod Med 57, no. 3-4 (March 2012): 171-174.
Yeh, JS, III, LCE, Hawkins, KC, Dai, Q, and Price, TM. "DETERMINATION OF CARDIAC HISTOLOGIC INJURY IN A TRANSGENIC MOUSE MODEL OF HEART FAILURE EXPRESSING A NOVEL MITOCHONDRIAL PROGESTERONE RECEPTOR (PR-M)." September 2011.
Peavey, MC, Shah, AA, Raburn, DJ, Walmer, DK, Copland, SD, and Price, TM. "ENDOMETRIAL INJURY VIA SALINE-INFUSION SONOHYSTEROGRAM (SIS) PERFORMED WITHIN ONE MONTH OF CYCLE START DOES NOT IMPROVE LIVE BIRTH RATE." September 2011.
Crochet, JR, Feng, Q, Dai, Q, Leppert, PC, and Price, TM. "MITOCHONDRIAL PROGESTERONE RECEPTOR (PR-M) DISTRIBUTION IN UTERINE LEIOMYOMA AND MYOMETRIUM AND IMPACT ON MITOCHONDRIAL MEMBRANE POTENTIAL (MMP) IN IMMORTILIZED HUMAN MYOMETRIAL CELLS (HTERT-HM)." September 2011.
III, LCE, Hawkins, KC, Mao, L, Dai, Q, Rockman, HA, and Price, TM. "PROGESTERONE VIA A MITOCHONDRIAL PROGESTERONE RECEPTOR (PR-M) PREVENTS HEART FAILURE IN A TRANSGENIC MOUSE MODEL OF AORTIC CONSTRICTION." September 2011.
Zhang, A, Skaar, DA, Li, Y, Huang, D, Price, TM, Murphy, SK, and Jirtle, RL. "Novel retrotransposed imprinted locus identified at human 6p25." Nucleic Acids Res 39, no. 13 (July 2011): 5388-5400.
Hawkins, KC, Mu, KE, Christopher, PS, Miller, SE, Oliver, TN, and Price, TM. "The Role of a Mitochondrial Progesterone Receptor (PR-M) in Human Spermatozoa Function." REPRODUCTIVE SCIENCES 18, no. 3 (March 2011): 262A-263A.
Manuck, TA, Price, TM, Thom, E, Meis, PJ, Dombrowski, MP, Sibai, B, Spong, CY, Rouse, DJ, Iams, JD, Simhan, HN, O'Sullivan, MJ, Miodovnik, M, Leveno, KJ, Conway, D, Wapner, RJ, Carpenter, M, Mercer, B, Ramin, SM, Thorp, JM, Peaceman, AM, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network, . "Absence of mitochondrial progesterone receptor polymorphisms in women with spontaneous preterm birth." Reproductive sciences (Thousand Oaks, Calif.) 17, no. 10 (October 2010): 913-916.