Crochet, JR, Hawkins, KC, Peavey, MC, Price, TM, Walmer, DK, and Copland, SD. "PREGNANCY IN THE SETTING OF LOW AND UNDETECTABLE SERUM ANTI-MULLERIAN HORMONE (AMH)." September 2010.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- Endocrinology and Metabolism Training Program
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Lee, KL, Dai, Q, Hansen, EL, Saner, CN, and Price, TM. "Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells." Mol Cell Endocrinol 319, no. 1-2 (May 5, 2010): 109-115.
Shah, AA, Dai, Q, Miller, SE, Christopher, PS, and Price, TM. "Localization of a Novel Truncated Progesterone Receptor, PR-M, to the Outer Mitochondrial Membrane in Human Myornetrial Tissue." March 2010.
Dai, Q, and Price, TM. "RNA Interference in T47D Breast Cancer Cells Demonstrates Control of Mitochondrial Activity by a Mitochondrial Progesterone Receptor (PR-M)." March 2010.
Forman, EJ, Guyton, JR, Filip, SJ, and Price, TM. "Implanted estrogen pellets associated with hypertriglyceridemia, biliary dyskinesia and focal nodular hyperplasia of the liver: a case report." J Reprod Med 55, no. 1-2 (January 2010): 87-90.
Behera, MA, Dai, Q, Garde, R, Saner, C, Jungheim, E, and Price, TM. "Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells." Am J Physiol Endocrinol Metab 297, no. 5 (November 2009): E1089-E1096.
Shah, AA, Likes, CE, and Price, TM. "Early polycystic ovary syndrome as a possible etiology of unexplained premenarcheal ovarian torsion." J Pediatr Adolesc Gynecol 22, no. 4 (August 2009): 265-269.
Gavrilova-Jordan, LP, Zhang, L, Schomberg, D, Jayes, FL, Feng, L, and Price, TM. "Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues." March 2009.
Gavrilova-Jordan, LP, Schomberg, D, Feng, L, Jayes, FL, Murtha, A, and Price, TM. "Expression of a Truncated Progesterone Receptor Isoform (PR-M) in Pregnant and Laboring Myometrium." March 2009.
Murphy, SK, Huang, Z, Wen, Y, Simel, LR, Price, TM, and Berchuck, A. "Intragenic methylation at a novel CTCF binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer." GYNECOLOGIC ONCOLOGY 112, no. 2 (February 2009): S138-S138.