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Thomas Michael Price, MD

Thomas Price, MD
Professor of Obstetrics and Gynecology
Campus Mail: 236 Sands Bldg, Durham, NC 27710
Phone: (919) 684-4673
Email: thomas.m.price@duke.edu

Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Education and Training

  • REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
  • Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
  • M.D., University of North Carolina at Chapel Hill, 1984

Certifications

  • American Board of Obstetrics and Gynecology, 1992
  • American Board of Reproductive Endocrinology and Infertility, 1994

Research

Dr. Price has been  involved in basic science and clinical research since completing training in 1991.  His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor. 

His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

 Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD.  I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.  

Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery. 

View Publications

Publications

Crochet, JR, Hawkins, KC, Peavey, MC, Price, TM, Walmer, DK, and Copland, SD. "PREGNANCY IN THE SETTING OF LOW AND UNDETECTABLE SERUM ANTI-MULLERIAN HORMONE (AMH)." September 2010.

Full Text

Lee, KL, Dai, Q, Hansen, EL, Saner, CN, and Price, TM. "Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells." Mol Cell Endocrinol 319, no. 1-2 (May 5, 2010): 109-115.

Full Text

Shah, AA, Dai, Q, Miller, SE, Christopher, PS, and Price, TM. "Localization of a Novel Truncated Progesterone Receptor, PR-M, to the Outer Mitochondrial Membrane in Human Myornetrial Tissue." March 2010.

Scholars@Duke

Dai, Q, and Price, TM. "RNA Interference in T47D Breast Cancer Cells Demonstrates Control of Mitochondrial Activity by a Mitochondrial Progesterone Receptor (PR-M)." March 2010.

Scholars@Duke

Forman, EJ, Guyton, JR, Filip, SJ, and Price, TM. "Implanted estrogen pellets associated with hypertriglyceridemia, biliary dyskinesia and focal nodular hyperplasia of the liver: a case report." J Reprod Med 55, no. 1-2 (January 2010): 87-90.

Scholars@Duke

Behera, MA, Dai, Q, Garde, R, Saner, C, Jungheim, E, and Price, TM. "Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells." Am J Physiol Endocrinol Metab 297, no. 5 (November 2009): E1089-E1096.

Full Text

Shah, AA, Likes, CE, and Price, TM. "Early polycystic ovary syndrome as a possible etiology of unexplained premenarcheal ovarian torsion." J Pediatr Adolesc Gynecol 22, no. 4 (August 2009): 265-269.

Full Text

Gavrilova-Jordan, LP, Zhang, L, Schomberg, D, Jayes, FL, Feng, L, and Price, TM. "Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

Gavrilova-Jordan, LP, Zhang, L, Schomberg, D, Jayes, FL, Feng, L, and Price, TM. "Expression of a Truncated Progesterone Receptor (PR-M) Correlates with Mitochondrial Content in Human Tissues." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

Gavrilova-Jordan, LP, Schomberg, D, Feng, L, Jayes, FL, Murtha, A, and Price, TM. "Expression of a Truncated Progesterone Receptor Isoform (PR-M) in Pregnant and Laboring Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.

Scholars@Duke

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