Gavrilova-Jordan, LP, Schomberg, D, Feng, L, Jayes, FL, Murtha, A, and Price, TM. "Expression of a Truncated Progesterone Receptor Isoform (PR-M) in Pregnant and Laboring Myometrium." 56th Annual Meeting of the Society-for-Gynecologic-Investigation. Glasgow, SCOTLAND. March 17, 2009 - March 21, 2009. SAGE PUBLICATIONS INC, March 1, 2009.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Murphy, SK, Huang, Z, Wen, Y, Simel, LR, Price, TM, and Berchuck, A. "Intragenic methylation at a novel CTCF binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer." GYNECOLOGIC ONCOLOGY 112, no. 2 (February 2009): S138-S138.
Tantibhedhyangkul, J, Copland, SD, Haqq, AM, and Price, TM. "A case of female epispadias." Fertil Steril 90, no. 5 (November 2008): 2017.e1-2017.e3.
Myers, ER, McCrory, DC, Mills, AA, Price, TM, Swamy, GK, Tantibhedhyangkul, J, Wu, JM, and Matchar, DB. "Effectiveness of assisted reproductive technology (ART)." Evidence Report/Technology Assessment, no. 167 (May 2008): 1-195. (Review)
Dai, Q, Behera, MA, and Price, TM. "Progesterone/progestin increases cellular respiration in cells expressing an outer membrane mitochondrial truncated progesterone receptor." February 2008.
Diesen, DL, Price, TM, and Skinner, MA. "Uterine leiomyoma in a 14-year-old girl." Eur J Pediatr Surg 18, no. 1 (February 2008): 53-55. (Review)
James, AH, Brancazio, LR, and Price, T. "Aspirin and reproductive outcomes." Obstet Gynecol Surv 63, no. 1 (January 2008): 49-57. (Review)
Gavrilova-Jordan, LP, and Price, TM. "Actions of steroids in mitochondria." Semin Reprod Med 25, no. 3 (May 2007): 154-164. (Review)
Lacy, J, Correll, GR, Walmer, DK, and Price, TM. "Simple vaginal mold for use in the postoperative care of patients with a transverse vaginal septum." Fertil Steril 87, no. 5 (May 2007): 1225-1226.
Price, TM, Murphy, SK, and Younglai, EV. "Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors." Toxicol Sci 96, no. 2 (April 2007): 218-226. (Review)