Behera, M, Price, T, and Walmer, D. "Estrogenic ovulatory dysfunction or functional female hyperandrogenism: an argument to discard the term polycystic ovary syndrome." Fertil Steril 86, no. 5 (November 2006): 1292-1295.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- Endocrinology and Metabolism Training Program
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Garde, RV, Jovanovic, VP, Couchman, GM, Walmer, DK, and Price, TM. "Ectopic pregnancy in a preexisting hydrosalpinx during a spontaneous pregnancy." Fertil Steril 86, no. 4 (October 2006): 1001.e11-1001.e13.
Younglai, EV, Wu, Y, Foster, WG, Lobb, DK, and Price, TM. "Binding of progesterone to cell surfaces of human granulosa-lutein cells." J Steroid Biochem Mol Biol 101, no. 1 (September 2006): 61-67.
Garde, RV, Saner, CN, and Price, TM. "Discovery of a truncted progesterone receptor (PR-M) in the mitochondria." February 2006.
Garde, RV, Saner, CN, and Price, TM. "Identification of a novel truncated progesterone receptor (PR-M) in breast cancers and breast cancer cell lines." February 2006.
Price, TM, Hansen, EL, and Oliver, TN. "Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression." J Soc Gynecol Investig 12, no. 8 (December 2005): 610-616.
Payne, JF, Raburn, DJ, Couchman, GM, Price, TM, Jamison, MG, and Walmer, DK. "Relationship between pre-embryo pronuclear morphology (zygote score) and standard day 2 or 3 embryo morphology with regard to assisted reproductive technique outcomes." Fertil Steril 84, no. 4 (October 2005): 900-909.
Payne, JF, Raburn, DJ, Couchman, GM, Price, TM, Jamison, MG, and Walmer, DK. "Redefining the relationship between sperm deoxyribonucleic acid fragmentation as measured by the sperm chromatin structure assay and outcomes of assisted reproductive techniques." Fertil Steril 84, no. 2 (August 2005): 356-364.
Behera, M, Couchman, G, Walmer, D, and Price, TM. "Mullerian agenesis and thrombocytopenia absent radius syndrome: a case report and review of syndromes associated with Mullerian agenesis." Obstet Gynecol Surv 60, no. 7 (July 2005): 453-461. (Review)
Price, TM, Herbst, SJ, Harris, MS, Prethus, JB, Anderson, TL, and Grainger, DA. "Permanent transcervical sterilization: The first 500 women treated in a multicenter trial." April 2005.