Lee, KL, Hansen, EL, and Price, TM. "Characterization of a novel non-genomic truncated progesterone receptor." September 2004.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- Endocrinology and Metabolism Training Program
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Payne, JF, Raburn, DJ, Couchman, GM, Price, TM, Jamison, MG, and Walmer, DK. "Redefining the relationship between sperm DNA fragmentation as measured by the Sperm Chromatin Structure Assay (SCSA (R)) and outcomes of assisted reproductive techniques (ART)." September 2004.
Payne, JF, Raburn, DJ, Couchman, GM, Price, TM, Jamison, MG, and Walmer, DK. "The relationship between embryo pronuclear morphology (Zygote score) and standard day 2 or 3 embryo morphology on assisted reproductive technique outcomes." September 2004.
Crane, MM, Divine, GW, Blackhurst, DW, Black, CL, Higdon, HL, Price, TM, and Boone, WR. "Conclusions about the effects on fertilization of time from aspiration to incubation and blood in the aspirate depend on the use of appropriate statistical techniques." Fertil Steril 81, no. 6 (June 2004): 1548-1553.
Welter, BH, Hansen, EL, Saner, KJ, Wei, Y, and Price, TM. "Membrane-bound progesterone receptor expression in human aortic endothelial cells." J Histochem Cytochem 51, no. 8 (August 2003): 1049-1055.
Saner, KJ, Welter, BH, Zhang, F, Hansen, E, Dupont, B, Wei, Y, and Price, TM. "Cloning and expression of a novel, truncated, progesterone receptor." Mol Cell Endocrinol 200, no. 1-2 (February 28, 2003): 155-163.
Kerin, JF, Cooper, JM, Price, T, Herendael, BJV, Cayuela-Font, E, Cher, D, and Carignan, CS. "Hysteroscopic sterilization using a micro-insert device: Results of a multicentre Phase II study." Human Reproduction 18, no. 6 (2003): 1223-1230.
McCubbin, JA, Helfer, SG, Switzer, FS, and Price, TM. "Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease." Am Heart J 143, no. 4 (April 2002): 711-717.
Miller, PB, Price, T, Jr, JEN, and Hill, L. "Acute ureteral obstruction following transvaginal oocyte retrieval for IVF." Human Reproduction 17, no. 1 (2002): 137-138.
Price, TM, and Harris, JB. "Fulminant hepatic failure due to herpes simplex after hysteroscopy." Obstet Gynecol 98, no. 5 Pt 2 (November 2001): 954-956.