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Thomas Michael Price, MD

Thomas Price, MD
Professor of Obstetrics and Gynecology
Campus Mail: 236 Sands Bldg, Durham, NC 27710
Phone: (919) 684-4673
Email: thomas.m.price@duke.edu

Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Education and Training

  • REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
  • Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
  • M.D., University of North Carolina at Chapel Hill, 1984

Certifications

  • American Board of Obstetrics and Gynecology, 1992
  • American Board of Reproductive Endocrinology and Infertility, 1994

Research

Dr. Price has been  involved in basic science and clinical research since completing training in 1991.  His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor. 

His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

 Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD.  I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.  

Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery. 

View Publications

Publications

Behera, M, Couchman, G, Walmer, D, and Price, TM. "Mullerian agenesis and thrombocytopenia absent radius syndrome: a case report and review of syndromes associated with Mullerian agenesis." Obstet Gynecol Surv 60, no. 7 (July 2005): 453-461. (Review)

Scholars@Duke

Price, TM, Herbst, SJ, Harris, MS, Prethus, JB, Anderson, TL, and Grainger, DA. "Permanent transcervical sterilization: The first 500 women treated in a multicenter trial." April 2005.

Scholars@Duke

Lee, KL, Hansen, EL, and Price, TM. "Characterization of a novel non-genomic truncated progesterone receptor." September 2004.

Full Text

Payne, JF, Raburn, DJ, Couchman, GM, Price, TM, Jamison, MG, and Walmer, DK. "Redefining the relationship between sperm DNA fragmentation as measured by the Sperm Chromatin Structure Assay (SCSA (R)) and outcomes of assisted reproductive techniques (ART)." September 2004.

Full Text

Payne, JF, Raburn, DJ, Couchman, GM, Price, TM, Jamison, MG, and Walmer, DK. "The relationship between embryo pronuclear morphology (Zygote score) and standard day 2 or 3 embryo morphology on assisted reproductive technique outcomes." September 2004.

Full Text

Crane, MM, Divine, GW, Blackhurst, DW, Black, CL, Higdon, HL, Price, TM, and Boone, WR. "Conclusions about the effects on fertilization of time from aspiration to incubation and blood in the aspirate depend on the use of appropriate statistical techniques." Fertil Steril 81, no. 6 (June 2004): 1548-1553.

Full Text

Welter, BH, Hansen, EL, Saner, KJ, Wei, Y, and Price, TM. "Membrane-bound progesterone receptor expression in human aortic endothelial cells." The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society 51, no. 8 (August 2003): 1049-1055.

Full Text

Kerin, JF, Cooper, JM, Price, T, Herendael, BJV, Cayuela-Font, E, Cher, D, and Carignan, CS. "Hysteroscopic sterilization using a micro-insert device: results of a multicentre Phase II study." Human Reproduction (Oxford, England) 18, no. 6 (June 2003): 1223-1230.

Full Text

Saner, KJ, Welter, BH, Zhang, F, Hansen, E, Dupont, B, Wei, Y, and Price, TM. "Cloning and expression of a novel, truncated, progesterone receptor." Mol Cell Endocrinol 200, no. 1-2 (February 28, 2003): 155-163.

Scholars@Duke

McCubbin, JA, Helfer, SG, Switzer, FS, and Price, TM. "Blood pressure control and hormone replacement therapy in postmenopausal women at risk for coronary heart disease." Am Heart J 143, no. 4 (April 2002): 711-717.

Scholars@Duke

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