Skip to main content

Thomas Michael Price, MD

Thomas Price, MD
Professor of Obstetrics and Gynecology
Campus Mail: 236 Sands Bldg, Durham, NC 27710
Phone: (919) 684-4673
Email: thomas.m.price@duke.edu

Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Education and Training

  • REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
  • Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
  • M.D., University of North Carolina at Chapel Hill, 1984

Certifications

  • American Board of Obstetrics and Gynecology, 1992
  • American Board of Reproductive Endocrinology and Infertility, 1994

Research

Dr. Price has been  involved in basic science and clinical research since completing training in 1991.  His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor. 

His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

 Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD.  I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.  

Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery. 

View Publications

Publications

Miller, PB, Price, T, Jr, JEN, and Hill, L. "Acute ureteral obstruction following transvaginal oocyte retrieval for IVF." Human Reproduction 17, no. 1 (2002): 137-138.

Scholars@Duke

Price, TM, and Harris, JB. "Fulminant hepatic failure due to herpes simplex after hysteroscopy." Obstet Gynecol 98, no. 5 Pt 2 (November 2001): 954-956.

Scholars@Duke

Price, TM, and Harris, JB. "Fulminant hepatic failure due to herpes simplex after hysteroscopy." Obstetrics and Gynecology 98, no. 5 SUPPL. 1 (2001): 954-956.

Full Text

Price, TM, Allen, S, and Pegram, GV. "Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone." Fertil Steril 74, no. 2 (August 2000): 414-415. (Letter)

Scholars@Duke

Thoennes, SR, Tate, PL, Price, TM, and Kilgore, MW. "Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells." Mol Cell Endocrinol 160, no. 1-2 (February 25, 2000): 67-73.

Scholars@Duke

Welter, BH, and Price, TM. "Magnetic separation to concentrate the estrogen receptor from adipose tissue for western analysis." Biotechniques 27, no. 2 (August 1999): 282-286.

Full Text

O'brien, SN, Welter, BH, and Price, TM. "Presence of leptin in breast cell lines and breast tumors." Biochem Biophys Res Commun 259, no. 3 (June 16, 1999): 695-698.

Full Text

Boone, WR, Johnson, JE, Locke, AJ, Crane, MM, and Price, TM. "Control of air quality in an assisted reproductive technology laboratory." Fertil Steril 71, no. 1 (January 1999): 150-154.

Scholars@Duke

Price, TM. "Finasteride for hirsutism." Contemporary Ob-Gyn 44, no. 11 (1999): 73-84.

Scholars@Duke

Price, TM. "Finasteride for hirsutism." Emergency Medicine 44, no. 11 (1999): 73-84.

Scholars@Duke

Pages