Price, TM, and Harris, JB. "Fulminant hepatic failure due to herpes simplex after hysteroscopy." Obstetrics and Gynecology 98, no. 5 SUPPL. 1 (2001): 954-956.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- Endocrinology and Metabolism Training Program
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Price, TM, Allen, S, and Pegram, GV. "Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone." Fertil Steril 74, no. 2 (August 2000): 414-415. (Letter)
Thoennes, SR, Tate, PL, Price, TM, and Kilgore, MW. "Differential transcriptional activation of peroxisome proliferator-activated receptor gamma by omega-3 and omega-6 fatty acids in MCF-7 cells." Mol Cell Endocrinol 160, no. 1-2 (February 25, 2000): 67-73.
Welter, BH, and Price, TM. "Magnetic separation to concentrate the estrogen receptor from adipose tissue for western analysis." Biotechniques 27, no. 2 (August 1999): 282-286.
O'brien, SN, Welter, BH, and Price, TM. "Presence of leptin in breast cell lines and breast tumors." Biochem Biophys Res Commun 259, no. 3 (June 16, 1999): 695-698.
Boone, WR, Johnson, JE, Locke, AJ, Crane, MM, and Price, TM. "Control of air quality in an assisted reproductive technology laboratory." Fertil Steril 71, no. 1 (January 1999): 150-154.
Price, TM. "Finasteride for hirsutism." Contemporary Ob-Gyn 44, no. 11 (1999): 73-84.
Price, TM. "Finasteride for hirsutism." Emergency Medicine 44, no. 11 (1999): 73-84.
Culligan, PJ, Crane, MM, Boone, WR, Allen, TC, Price, TM, and Blauer, KL. "Validity and cost-effectiveness of antisperm antibody testing before in vitro fertilization." Fertil Steril 69, no. 5 (May 1998): 894-898.
O'Brien, SN, Welter, BH, Mantzke, KA, and Price, TM. "Identification of progesterone receptor in human subcutaneous adipose tissue." J Clin Endocrinol Metab 83, no. 2 (February 1998): 509-513.