Price, TM, O'Brien, SN, Welter, BH, George, R, Anandjiwala, J, and Kilgore, M. "Estrogen regulation of adipose tissue lipoprotein lipase - Possible mechanism of body fat distribution." American Journal of Obstetrics and Gynecology 178, no. 1 I (1998): 101-107.
Thomas Michael Price, MD
Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Education and Training
- REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
- Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
- M.D., University of North Carolina at Chapel Hill, 1984
- American Board of Obstetrics and Gynecology, 1992
- American Board of Reproductive Endocrinology and Infertility, 1994
Dr. Price has been involved in basic science and clinical research since completing training in 1991. His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.
Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD. I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.
Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery.
Selected Grants and Awards
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis
- Treatment of Uterine Fibroids by ExAblate MR guided FUS- Long Term Followup
- Endocrinology and Metabolism Training Program
- The Impact of Chronic Endometritis on IVF Pregnancy and Miscarriage Rates
- Treatment of Uterine Fibroids by ExAblate MR guided FUS
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats
- The role of progesterone in early embryo metabolism and development in the Rhesus primate (Macaca mulatta).
- Cardiac Effects of a Mitochondrial Progesterone Receptor
- Modulation of mitochondrial calcium by a novel progesterone receptor
- Effectiveness and Efficiency of Assisted Reproductive Technology
Price, TM, O'Brien, SN, Welter, BH, George, R, Anandjiwala, J, and Kilgore, M. "Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution." Am J Obstet Gynecol 178, no. 1 Pt 1 (January 1998): 101-107.
O'Brien, SN, Anandjiwala, J, and Price, TM. "Differences in the estrogen content of breast adipose tissue in women by menopausal status and hormone use." Obstet Gynecol 90, no. 2 (August 1997): 244-248.
Kilgore, MW, Tate, PL, Rai, S, Sengoku, E, and Price, TM. "MCF-7 and T47D human breast cancer cells contain a functional peroxisomal response." Mol Cell Endocrinol 129, no. 2 (May 16, 1997): 229-235.
Price, TM, Blauer, KL, Hansen, M, Stanczyk, F, Lobo, R, and Bates, GW. "Single-dose pharmacokinetics of sublingual versus oral administration of micronized 17 beta-estradiol." Obstet Gynecol 89, no. 3 (March 1997): 340-345.
Jones, GB, Kilgore, MW, Pollenz, RS, Li, A, Mathews, JE, Wright, JM, Huber, RS, Tate, PL, Price, TL, and Sticca, RP. "Target directed enediyne prodrugs: hER and AhR degradation by a synthetic oxo-enediyne." Bioorganic & Medicinal Chemistry Letters 6, no. 16 (August 1996): 1971-1976.
O'Brien, SN, Mantzke, KA, Kilgore, MW, and Price, TM. "Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue." Anal Quant Cytol Histol 18, no. 2 (April 1996): 137-143.
Boone, WR, Johnson, JE, Price, TM, Bowers, BK, Morris, MD, Crane, MM, and Bates, GW. "In vitro fertilization and embryo transfer (IVF-ET) comes to the upstate." J S C Med Assoc 90, no. 8 (August 1994): 360-366.
Price, TM, Allen, TC, Bowyer, DL, and Watson, TA. "Ablation of luteal phase symptoms of Menière's disease with leuprolide." Arch Otolaryngol Head Neck Surg 120, no. 2 (February 1994): 209-211.
Bulun, SE, Price, TM, Aitken, J, Mahendroo, MS, and Simpson, ER. "Erratum: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription (Journal of Clinical Endocrinology and Metabolism (1993) 77 (1622-1628))." Journal of Clinical Endocrinology and Metabolism 78, no. 2 (1994): 494--.