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Liping Feng, MD

Property title
Assistant Professor of Obstetrics and Gynecology
Campus Mail: 303 Research Drive, 246 Sands, Durham, NC 27710
Phone: (919) 613-1459
Email: feng0007@mc.duke.edu

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Education and Training

  • M.S., Chinese Center for Disease Control and Prevention (China), 2000
  • M.D., Harbin Medical University (China), 1997

Research

My research has focused on understanding the mechanisms of pregnancy complications associated with infection and maternal chemical exposures. These works are translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of adverse birth outcomes.

Liping Feng, MD, devotes her entire career to improving pregnancy outcomes through innovative research. Dr. Feng conducts both basic science/laboratory research, as well as participates in clinical studies. Her laboratory has focused on understanding the mechanisms of preterm birth, which is an important cause of perinatal and neonates’ mortality and morbidity. Currently, she has three lines of investigation focused on the roles of inflammation/infection, genetic variation, and environmental exposure in pregnancy complications, such as preterm birth and preeclampsia. This work is translated then to the clinical care of women through studies dedicated to identify risk factors and novel biomarkers for early prediction and prevention of pregnancy complications.

In addition, Dr. Feng has established an international collaboration in Global Women’s Health. She has recently affiliated with the Duke Global Health Institute (DGHI) and participates in a DGHI research. She has an interest in DGHI education, and service or policy initiatives, including mentoring and teaching graduate and professional students on fieldwork and research.

Projects

  • Understanding chemical exposure of PFBS during pregnancy and birth outcomes using in vitro and in vivo models. Using these models established in my lab, we could also test other environmental exposures

  • Investigating the impact of E-waste recycling and birth outcomes in China (Global health)

  • Building a novel in vitro placental model (collaboration with BME) to explore the mechanisms of ZIKA virus in utero transmission

  • Determine the roles of an understudied bacteria, Ureaplasma, in pregnancy

Publications

Ye, Y, Tang, Y, Xiong, Y, Feng, L, and Li, X. "Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology (October 10, 2018): fj201800934RRR-null.

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Ye, J, Chen, Y, Zhu, J, Chen, C, Zhu, X, Feng, L, Ye, W, and Zhang, J. "Aspirin use during pregnancy and hypoxia-related placental pathology." Pregnancy Hypertension 14 (October 1, 2018): 177-188.

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Feng, L. "Reply." American Journal of Obstetrics and Gynecology (September 29, 2018). (Letter)

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Feng, L, Allen, TK, Marinello, WP, and Murtha, AP. "Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM)." American Journal of Obstetrics and Gynecology 219, no. 1 (July 2018): 101.e1-101.e12.

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Allen, TK, Marinello, W, Feng, L, Murtha, A, and Buhimschi, I. "Progestins Inhibit IL1b-Induced MMP1 and IL8 mRNA Expression in Amnion Mesenchymal Cells through the Glucocorticoid Receptor." 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI). San Diego, CA. March 6, 2018 - March 10, 2018.: SAGE PUBLICATIONS INC, March 1, 2018.

Scholars@Duke

Allen, TK, Marinello, W, Feng, L, Murtha, A, and Buhimschi, I. "Progestins Inhibit IL1b-Induced MMP1 and IL8 mRNA Expression in Amnion Mesenchymal Cells through the Glucocorticoid Receptor." 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI). San Diego, CA. March 6, 2018 - March 10, 2018.: SAGE PUBLICATIONS INC, March 1, 2018.

Scholars@Duke

Feng, L, Allen, TK, Marinello, WP, and Murtha, AP. "Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells." Reproductive Sciences (Thousand Oaks, Calif.) (January 2018): 1933719118776790-null.

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Ye, Y, Zhou, Q, Feng, L, Wu, J, Xiong, Y, and Li, X. "Maternal serum bisphenol A levels and risk of pre-eclampsia: a nested case-control study." The European Journal of Public Health 27, no. 6 (December 2017): 1102-1107.

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Smrtka, MP, Feng, L, Murtha, AP, and Grotegut, CA. "Thrombin-Induced Inflammation in Human Decidual Cells Is Not Affected By Heparin." Reproductive Sciences (Thousand Oaks, Calif.) 24, no. 8 (August 2017): 1154-1163.

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Wang, X, Ouyang, F, Feng, L, Wang, X, Liu, Z, and Zhang, J. "Maternal Urinary Triclosan Concentration in Relation to Maternal and Neonatal Thyroid Hormone Levels: A Prospective Study." Environmental Health Perspectives 125, no. 6 (June 27, 2017): 067017-null.

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