Society for Maternal-Fetal Medicine (SMFM), , Sadovsky, Y, Caughey, AB, DiVito, M, D'Alton, ME, Murtha, AP, and SMFM Research Committee, . "Research to knowledge: promoting the training of physician-scientists in the biology of pregnancy." American journal of obstetrics and gynecology 218, no. 1 (January 2018): B9-B13.
Amy Patricia Murtha, MD
Dr. Amy Murtha is a Professor in the Department of Obstetrics and Gynecology and Department of Pediatrics, and past Vice Chair for Research in Obstetrics and Gynecology. After graduating from the Medical College of Pennsylvania in 1992 she completed her residency in OB-GYN and fellowship in Maternal Fetal Medicine (MFM) at Duke University then joined the faculty at Duke in 1998.
Dr. Murtha served as interim Chair for the Department of OB-GYN and Fellowship Director for the maternal fetal medicine division. She is currently Clinical Research Unit (CRU) Director and Program Director for the NIH-funded K12 training grant Building Interdisciplinary Research Careers in Women’s Health (BIRCWH). As a leader in research administration, Dr. Murtha has created an environment for the oversight of research in a way that is beneficial to the entire enterprise.
Dr. Murtha’s research career has focused primarily on preterm delivery and specifically on preterm premature rupture of membranes (PPROM). As a clinician scientist, she has the unique perspective of understanding the clinical implications of both basic and laboratory research. The Perinatal Research Initiative, led by Dr. Murtha and funded through philanthropic dollars, has allowed for growth in the size and scope of her lab. In addition to advancing the understanding of the etiology of preterm birth she has also focused on training the next generation of physician scientists in translational and molecular biology techniques with over 75 publications. Dr. Murtha uses her experiences and leadership skills to create an environment of supportive, collaborative, financially responsible research at Duke that aligns with the missions of the School of Medicine and the Duke University Health System.
Education and Training
- Resident, Obstetrics & Gynecology, Duke University, 1992 - 1996
- M.D., Drexel University, 1992
Selected Grants and Awards
- Building Interdisciplinary Research Careers in Women's Health
- Effects of perfluorobutane sulfonate (PFBS) exposure on adverse pregnancy outcomes and fetal development
- Hypoxic Ischemic Encephalopathy-Phase II-Robertson Foundation
- Endocrinology and Metabolism Training Program
- Novel Coherence Imaging to Evaluate the Health of the Cervical Epithelium
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program
- Role of the Vaginal Microbiome in Preterm Birth
- Novel Determination of Microbicide PK in Women's Reproductive Health
- Role of GRK6-Mediated Oxytocin Receptor Desensitization in Labor
- Obesity and deregulation of imprinted genes in early life
- Pregnancy Outcomes and 17P
- Nutrition, Deregulation of Imprinted Genes
- Preterm Delivery Impacts Reproductive Health: Understanding the Etiology
- In-utero Exposure and Infant Loss of IGF2 Imprinting
- Neuromuscular Injury and Recovery after Vaginal Delivery
Gyamfi-Bannerman, C, Menon, R, Bonney, EA, Dolan, SM, Johnson, M, Lamont, RF, Mesiano, S, Murtha, AP, Myatt, L, Mysorekar, I, Williams, SM, Zhong, N, and Helmer, H. "Novel thoughts on preterm birth research proceedings of the 13th annual preterm birth international collaborative (PREBIC) meeting." Seminars in perinatology 41, no. 7 (November 2017): 438-441. (Review)
McCullough, LE, Miller, EE, Calderwood, LE, Shivappa, N, Steck, SE, Forman, MR, A Mendez, M, Maguire, R, Fuemmeler, BF, Kollins, SH, D Bilbo, S, Huang, Z, Murtha, AP, Murphy, SK, Hébert, JR, and Hoyo, C. "Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?." Epigenetics 12, no. 8 (August 2017): 688-697.
Smrtka, MP, Feng, L, Murtha, AP, and Grotegut, CA. "Thrombin-Induced Inflammation in Human Decidual Cells Is Not Affected By Heparin." Reproductive sciences (Thousand Oaks, Calif.) 24, no. 8 (August 2017): 1154-1163.
Benjamin Neelon, SE, White, AJ, Vidal, AC, Schildkraut, JM, Murtha, AP, Murphy, SK, Kullman, SW, and Hoyo, C. "Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years." International journal of obesity (2005) (July 5, 2017).
Allen, TK, Feng, L, Marinello, W, Buhimischi, IA, and Murtha, AP. "Progestins Inhibit IL1 beta Induced MMP9 Activity and GM-CSF Production from Primary Chorion Cells." March 2017.
Edwards, J, Truong, T, Li, Y-J, Grotegut, CA, and Murtha, AP. "MMP activation in human fetal membranes by TNF-alpha and Ureaplasma parvum." January 2017.
Ho, D, Chu, KK, Crose, M, Desoto, M, Peters, JJ, Murtha, AP, and Wax, A. "Novel multiplexed low coherence interferometry endoscopic probe for analyzing the cervical epithelium in vivo." 2017.
Ahmadzia, HK, Lockhart, EL, Thomas, SM, Welsby, IJ, Hoffman, MR, James, AH, Murtha, AP, Swamy, GK, and Grotegut, CA. "Using antifibrinolytics in the peripartum period - concern for a hypercoagulable effect?." Journal of neonatal-perinatal medicine 10, no. 1 (January 2017): 1-7.
Meng, Y, Murtha, AP, and Feng, L. "Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells." Reproductive sciences (Thousand Oaks, Calif.) 23, no. 9 (September 2016): 1168-1178.