Skip to main content

Thomas Michael Price, MD

Thomas Price, MD
Professor of Obstetrics and Gynecology
Campus Mail: 236 Sands Bldg, Durham, NC 27710
Phone: (919) 684-4673
Email: thomas.m.price@duke.edu

Dr. Price is involved in both clinical and basic science research. The main focus of the basic science molecular endocrinology laboratory is the study of novel sex steroid receptors. Currently, the work focuses on a novel progesterone receptor that localizes to the mitochondrion. Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor.
Dr. Price also participates in clinical research endeavors. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

Education and Training

  • REI Fellowship, Ob/Gyn Rei, University of Texas at Dallas, 1989 - 1991
  • Internship & Residency, Obstetrics & Gynecology, University of North Carolina at Chapel Hill, 1985 - 1989
  • M.D., University of North Carolina at Chapel Hill, 1984

Certifications

  • American Board of Obstetrics and Gynecology, 1992
  • American Board of Reproductive Endocrinology and Infertility, 1994

Research

Dr. Price has been  involved in basic science and clinical research since completing training in 1991.  His laboratory has run continuously since that time without interruption. Since 2000 his basic research has focused on the discovery of a mitochondrial progesterone receptor.  Studies including RNAi in cell models and creation of transgenic mice are ongoing to discover the function of this receptor. The overall hypothesis is that progesterone modulates mitochondrial activity to meet the increased cellular energy demands of pregnancy via this receptor. 

His clinical research includes approximately 36 trials including self-initiated and industry sponsored. These projects are constantly changing and focus on many aspects of reproductive endocrinology including ovarian preservation during chemotherapy, treatments for menorrhagia, endometriosis, leiomyomata and infertility.

 Funding organizations for self-initiated research have included American Health Assistance Foundation, Pardee Foundation, American Heart Association, ACOG, Department of Defense, SGI, and NIH/NICHD.  I am a sub-PI for a T-32 grant at Duke held by Medical Endocrinology.  

Dr. Price has a patent pending on a device he designed for insertion of intra-uterine triangular balloon stents after hysteroscopy surgery. 

View Publications

Publications

Barnard, EP, Abdelmagied, AM, Vaughan, LE, Weaver, AL, Laughlin-Tommaso, SK, Hesley, GK, Woodrum, DA, Jacoby, VL, Kohi, MP, Price, TM, Nieves, A, Miller, MJ, Borah, BJ, Gorny, KR, Leppert, PC, Peterson, LG, and Stewart, EA. "Periprocedural Outcomes Comparing Fibroid Embolization and Focused Ultrasound: A Randomized Controlled Trial and Comprehensive Cohort Analysis." Obstetrical and Gynecological Survey 72, no. 9 (September 1, 2017): 531-533.

Full Text

Barnard, EP, AbdElmagied, AM, Vaughan, LE, Weaver, AL, Laughlin-Tommaso, SK, Hesley, GK, Woodrum, DA, Jacoby, VL, Kohi, MP, Price, TM, Nieves, A, Miller, MJ, Borah, BJ, Gorny, KR, Leppert, PC, Peterson, LG, and Stewart, EA. "Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis." American journal of obstetrics and gynecology 216, no. 5 (May 2017): 500.e1-500.e11.

Full Text

Hoffman, K, Butt, CM, Webster, TF, Preston, EV, Hammel, SC, Makey, C, Lorenzo, AM, Cooper, EM, Carignan, C, Meeker, JD, Hauser, R, Soubry, A, Murphy, SK, Price, TM, Hoyo, C, Mendelsohn, E, Congleton, J, Daniels, JL, and Stapleton, HM. "Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States." Environmental science & technology letters 4, no. 3 (March 2017): 112-118.

Full Text

Murphy, SK, Keyhan, S, Guo, L, Tomins, K, Taylor, M, Joglekar, R, Huang, Z, Grenier, C, Liao, Y, Massarsky, A, Soubry, A, Lea, A, Burke, EE, Cauley, M, Hall, BJ, Lucas, JE, Hoyo, C, Di Giulio, RT, Levin, ED, and Price, TM. "Environmental Influence on Preconceptional and Gestational DNA Methylation Profiles." September 2016.

Scholars@Duke

AbdElmagied, AM, Vaughan, LE, Weaver, AL, Laughlin-Tommaso, SK, Hesley, GK, Woodrum, DA, Jacoby, VL, Kohi, MP, Price, TM, Nieves, A, Miller, MJ, Borah, BJ, Gorny, KR, Leppert, PC, Lemens, MA, and Stewart, EA. "Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial." American journal of obstetrics and gynecology 215, no. 3 (September 2016): 338.e1-338.e18.

Full Text

Barnhart, KT, Nakajima, ST, Puscheck, E, Price, TM, Baker, VL, and Segars, J. "Practice patterns, satisfaction, and demographics of reproductive endocrinologists: results of the 2014 Society for Reproductive Endocrinology and Infertility Workforce Survey." Fertility and sterility 105, no. 5 (May 2016): 1281-1286.

Full Text

Steward, RG, Bateman, LA, Slentz, C, Stanczyk, FZ, and Price, TM. "The impact of short-term depot-medroxyprogesterone acetate treatment on resting metabolic rate." Contraception 93, no. 4 (April 2016): 317-322.

Full Text

Barnard, EP, AbdElmagied, AM, Vaughan, LE, Laughlin-Tommaso, SK, Jacoby, VL, Price, TM, Hesley, GK, Woodrum, DA, Kohi, MP, Gorny, KR, and Stewart, EA. "Recovery Trajectory in a Randomized Controlled Trial (RCT) of Uterine Artery Embolization (UAE) and MR-Guided Focused Ultrasound (FUS)." March 2016.

Scholars@Duke

Sandoval, JS, Steward, RG, Chen, C, Li, YJ, Price, TM, and Muasher, SJ. "High peak estradiol/mature oocyte ratio predicts lower clinical pregnancy, ongoing pregnancy, and live birth rates in GnRH antagonist intracytoplasmic sperm injection cycles." Journal of Reproductive Medicine 61, no. 1 (February 1, 2016): 11-16.

Scholars@Duke

Sandoval, JS, Steward, RG, Chen, C, Li, Y-J, Price, TM, and Muasher, SJ. "High Peak Estradiol/Mature Oocyte Ratio Predicts Lower Clinical Pregnancy, Ongoing Pregnancy, and Live Birth Rates in GnRH Antagonist Intracytoplasmic Sperm Injection Cycles." The Journal of reproductive medicine 61, no. 1-2 (January 2016): 11-16.

Scholars@Duke

Pages