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Chad Aaron Grotegut, MD

Chad Grotegut, MD
Associate Professor of Obstetrics and Gynecology
Campus Mail: Box 3967 Med Ctr, Durham, NC 27710
Phone: (919) 681-5220
Email: chad.grotegut@duke.edu

Desensitization of the oxytocin receptor as an etiology for dysfunction labor and post-partum hemorrhage. The molecular mechanisms of preeclampsia and the protective role of cigarette smoke exposure.

Education and Training

  • Obstetrics & Gynecology, Maternal Fetal Medicine, Duke University, 2006 - 2009
  • Residency, Obstetrics & Gynecology, Duke University, 1999 - 2003
  • M.D., Temple University, 1999

Certifications

  • American Board of Obstetrics and Gynecology, Obstetrics and Gynecology
  • American Board of Obstetrics and Gynecology, Maternal-Fetal Medicine

Research

Dr. Grotegut conducts both basic science/laboratory research, as well as participate in running clinical studies.  His laboratory research interests primarily focus on the hormone oxytocin and in understanding the mechanisms of uterine contractility.  This work is translated then to the clinical care of women through studies dedicated to understanding normal and abnormal labor.  In addition to his work in labor, he is involved in understanding the role that medical conditions and complications have in pregnancy outcomes.     

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Publications

Edwards, JM, Edwards, LE, Swamy, GK, and Grotegut, CA. "Magnesium sulfate for neuroprotection in the setting of chorioamnionitis. (Accepted)" The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 31, no. 9 (May 2018): 1156-1160.

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Wood, AM, Post, AL, Swamy, GK, and Grotegut, CA. "Neonatal Outcomes Associated with Noncephalic Presentation at Delivery in Preterm Birth." American journal of perinatology (January 8, 2018).

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Grotegut, CA, Lewis, LL, Manuck, TA, Allen, TK, James, AH, Seco, A, and Deneux-Tharaux, C. "The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study." American journal of perinatology 35, no. 1 (January 2018): 78-83.

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Boatin, AA, Eckert, LO, Boulvain, M, Grotegut, C, Fisher, BM, King, J, Berg, M, Adanu, RMK, Reddy, U, Waugh, JJS, Gupta, M, Kochhar, S, and Kenyon, S. "Dysfunctional labor: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data." Vaccine 35, no. 48 (December 4, 2017): 6538-6545.

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Grotegut, CA, Ngan, E, Garrett, ME, Miranda, ML, Ashley-Koch, AE, and Swamy, GK. "The association of single-nucleotide polymorphisms in the oxytocin receptor and G protein-coupled receptor kinase 6 (GRK6) genes with oxytocin dosing requirements and labor outcomes." American journal of obstetrics and gynecology 217, no. 3 (September 2017): 367.e1-367.e9.

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Smrtka, MP, Feng, L, Murtha, AP, and Grotegut, CA. "Thrombin-Induced Inflammation in Human Decidual Cells Is Not Affected By Heparin." Reproductive sciences (Thousand Oaks, Calif.) 24, no. 8 (August 2017): 1154-1163.

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Feldman, CH, Grotegut, CA, and Rosenberg, PB. "The role of STIM1 and SOCE in smooth muscle contractility." Cell calcium 63 (May 2017): 60-65. (Review)

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Ahmadzia, HK, Lockhart, EL, Thomas, SM, Welsby, IJ, Hoffman, MR, James, AH, Murtha, AP, Swamy, GK, and Grotegut, CA. "Using antifibrinolytics in the peripartum period - concern for a hypercoagulable effect?." Journal of neonatal-perinatal medicine 10, no. 1 (January 2017): 1-7.

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Grotegut, CA. "Prevention of preeclampsia." The Journal of clinical investigation 126, no. 12 (December 2016): 4396-4398. (Review)

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James, AH, Grotegut, C, Ahmadzia, H, Peterson-Layne, C, and Lockhart, E. "Management of Coagulopathy in Postpartum Hemorrhage." Seminars in thrombosis and hemostasis 42, no. 7 (October 3, 2016): 724-731. (Review)

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