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Perinatal Research

Protocol Number

Study Name Formal Study Name Funding Source PI
Pro00074063 ENIGMA Expanded Noninvasive Genomic Medical Assessment: The ENIGMA Study. A Clinical Study To Evaluate The Relative Clinical Sensitivity, Specificity, And Performance Of  A Laboratory Developed Test As A Screening Test For Fetal Chromosomal Aneuploidy, Infection And Other Diseases, And RHD Genotyping In The General Population Of Pregnant Women Industry Sarah Ellestad, MD
Pro00074251 HEALTHY Whole blood specimen collection from healthy subjects Industry Sarah Ellestad, MD
Pro00071192 Tdap and Flu Vaccines in Pregnancy A Prospective, Randomized, Open-label Clinical Trial to Assess the Safety and Immunogenicity of Simultaneous versus Sequential Administration of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine and Inactivated Influenza Vaccine in Pregnant Women – Pilot Government Geeta Swamy, MD
Pro00070969 SAMPLES Whole Blood Specimen Collection From Pregnant Women Industry Sarah Ellestad, MD
Pro00064248 NEWBORN-1 A Randomized, Double-blind, Multicenter, Phase III Study Comparing the Efficacy and Safety of Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Government Chad Grotegut, MD
Pro00065829 PREPARE(RSV M301) A Phase 3, Randomized, Observer-Blind, Placebo-Controlled, Group-Sequential Study to Determine the Immunogenicity and Safety of a Respiratory Syncytial Virus (RSV) F Nanoparticle Vaccine with Aluminum in Healthy Third-trimester Pregnant Women; and Safety and Efficacy of Maternally Transferred Antibodies in Preventing RSV Disease in their Infants Industry Geeta Swamy, MD
Pro00070555 Cervical Imaging Coherence Imaging of the Cervical Epithelium Internal

Adam Wax, PhD (Biomedical Engineering)

Amy Murtha, MD (MD Investigator)

Pro00056695 CHAP Chronic Hypertension in Pregnancy Government Brenna Hughes, MD
Pro00068471 PRPLE Project on Preterm Labor Epigenetics March of Dimes Foundation Amy Murtha, MD
Pro00062227 Prematurity Prevention Registry Prematurity Prevention Registry Internal Sarahn Wheeler, MD
Pro00071899 Indomethacin PK Study PK of Indomethacin in Preterm Labor and Short Cervix Government Chad Grotegut, MD
Pro00033318 Premie Cord Blood Collection and Characterization of Umbilical Cord Units from Premature Deliveries Internal

Joanne Kurtzberg, MD

Jennifer Gilner, MD

Pro00080957 TREETOP A mulTicenter AssEssmEnt of sponTaneOus Preterm birthrisk predictor Industry Amy Murtha, MD
Pro00081594 OSA in Pregnant Women with Chronic Hypertension Obstructive Sleep Apnea Among Pregnant Women with Chronic Hypertension Foundation Jennifer Dominguez, MD
Pro00080325 BioQ A Double Blind, Multi-center, Randomized, Placebo-Controlled, Parallel group, Phase 3 Study to Evaluate the Efficacy and Safety of Ropivacaine 0.2% Pre-Filled Dispenser for the Treatment of Postsurgical Pain in Patients Undergoing Cesarean  Industry Ashraf Habib, MD

For more information, please call the OB Research Team at 919-613-9630 or email obresearch@duke.edu.