The Reproductive Biology and Perinatal Laboratory focuses on discovery and translational research in the following areas.
- a novel progesterone receptor
- the biology of uterine fibroids, specifically the role of fibrosis and injury in mediating fibroid development and growth
- the molecular mechanisms regulating preterm premature rupture of the membranes and the mechanisms by which progesterone may provide protection, especially via the transmembrane receptor PGRMC1
- the mechanisms by which ureaplasma may lead to preterm labor
- oxytocin receptor signaling related to oxytocin receptor desensitization and the identification of novel biased ligands that can overcome adverse clinical outcomes associated with oxytocin receptor desensitization
- molecular mechanisms by which cigarette smoking provides protection from preeclampsia.
The RBPL is a highly collaborative group that works together on discoveries to improve the health of women. In addition, the RBPL is an important education resource for our resident trainees in obstetric and gynecology as well as fellow trainees in reproductive endocrinology and fertility and maternal-fetal medicine.