Assistant Professor in the Division of Environmental Science and Policy
Overview
Margeaux Marbrey, PhD, is an Assistant Professor in the Division of Reproductive Sciences in the Department of Obstetrics and Gynecology at Duke University Medical Center.
Dr. Marbrey's research aim is to understand molecular regulators of early and mid pregnancy success using exposure paradigms and cutting-edge models to further understand human reproduction, promote healthy pregnancies and improve patient care. The Marbrey laboratory builds upon Dr. Marbrey's strong experience using innovative models and exposure systems to answer important questions in pregnancy that ultimately lead to public health awareness, risk assessment and preserved lives of mother and baby.
Dr. Marbrey received her PhD from Baylor College of Medicine while studying how progesterone signaling regulates implantation in a spatiotemporal manner under the mentorship of Dr. Francesco DeMayo. Dr. Marbrey then completed a postdoctoral fellowship at the University of North Carolina Chapel Hill School of Medicine with Dr. Kathleen Caron discerning effects of toxicants, environmental exposures and tobacco products on pregnancy health, timing and disease.
Publications
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Marbrey, Margeaux W., Elizabeth S. Douglas, Emma R. Goodwin, and Kathleen M. Caron. “Coumestrol induces oxidative stress and impairs migration and embryonic growth.” Reproduction 166, no. 1 (April 20, 2023): 1–11. https://doi.org/10.1530/rep-23-0017.
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Li, Rong, Xiaoqiu Wang, Zhenyao Huang, Jayani Balaji, Tae Hoon Kim, Tianyuan Wang, Lecong Zhou, et al. “The role of epithelial progesterone receptor isoforms in embryo implantation.” Iscience 24, no. 12 (December 17, 2021): 103487. https://doi.org/10.1016/j.isci.2021.103487.
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Peavey, Mary C., San-Pin Wu, Rong Li, Jian Liu, Olivia M. Emery, Tianyuan Wang, Lecong Zhou, et al. “Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility.” Proc Natl Acad Sci U S A 118, no. 11 (March 16, 2021). https://doi.org/10.1073/pnas.2011643118.
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Wetendorf, Margeaux, Rong Li, San-Pin Wu, Jian Liu, Chad J. Creighton, Tianyuan Wang, Kyathanahalli S. Janardhan, et al. “Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms.” Sci Signal 13, no. 652 (October 6, 2020). https://doi.org/10.1126/scisignal.aaz9646.
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Quinn, Kelsey E., Brooke C. Matson, Margeaux Wetendorf, and Kathleen M. Caron. “Pinopodes: Recent advancements, current perspectives, and future directions.” Mol Cell Endocrinol 501 (February 5, 2020): 110644. https://doi.org/10.1016/j.mce.2019.110644.
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Wetendorf, Margeaux, Rong Li, San-Pin Wu, Jian Liu, Chad J. Creighton, Tianyuan Wang, Kyathanahalli S. Janardhan, et al. “Constitutive Expression of the Progesterone Receptor Isoforms Promotes Hormone-Dependent Development of Ovarian Neoplasms.” Cold Spring Harbor Laboratory, October 24, 2019. https://doi.org/10.1101/816934.
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Wetendorf, Margeaux, Lewis T. Randall, Mahlet T. Lemma, Sophia H. Hurr, John B. Pawlak, Robert Tarran, Claire M. Doerschuk, and Kathleen M. Caron. “E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero.” J Endocr Soc 3, no. 10 (October 1, 2019): 1907–16. https://doi.org/10.1210/js.2019-00216.
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Vasquez, Yasmin M., Xiaoqiu Wang, Margeaux Wetendorf, Heather L. Franco, Qianxing Mo, Tianyuan Wang, Rainer B. Lanz, et al. “FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation.” Plos Genet 14, no. 11 (November 2018): e1007787. https://doi.org/10.1371/journal.pgen.1007787.
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Hai, Lan, Maria M. Szwarc, Margeaux Wetendorf, San-Pin Wu, Mary C. Peavey, Sandra L. Grimm, Dean P. Edwards, Francesco J. DeMayo, and John P. Lydon. “A mouse model engineered to conditionally express the progesterone receptor-B isoform.” Genesis 56, no. 8 (August 2018): e23223. https://doi.org/10.1002/dvg.23223.
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Hai, Lan, Maria M. Szwarc, Margeaux Wetendorf, San-Pin Wu, Mary C. Peavey, Sandra L. Grimm, Dean P. Edwards, Francesco J. DeMayo, and John P. Lydon. “Cover Image, Volume 56, Issue 8.” Genesis 56, no. 8 (August 2018): e23247–e23247. https://doi.org/10.1002/dvg.23247.