Member of the Duke Cancer Institute
Overview
Zhiqing Huang, MD, PhD, is an Assistant Professor in the Division of Reproductive Sciences in the Department of Obstetrics and Gynecology at Duke University Medical Center.
Her research interests include identifying new biomarkers for ovarian cancer based on DNA methylation and gene expression profiles, studying the response of cancer stem cells to chemotherapy using a xenograft model and ovarian cancer cell lines and epigenetics.
Dr. Huang’s research focus also includes the roles of age-related changes in the tumor microenvironment on ovarian cancer progression, and drug development for ovarian cancer showing chemoresistance and recurrence. In the epigenetic research, she has involved the utilization of numerous techniques to address fundamental questions in cancer biology, and has developed new approaches on DNA methylation detection to accelerate discovery of epigenetic changes. Recently, she also has involved in the successful development of whole genome DNA methylation profiles using single human oocyte which is a pioneered approach in the field.
Publications
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Cassie, Hobbs, Coogan Isabella, Shin Jun Hee, Yao Derek Y, Neely Olivia, Jamshidi Parmida, Berchuck Andrew, Murphy Susan K, and Huang Zhiqing. “Toward understanding the roles of matrix metallopeptidase 1 in ovarian cancer.” Journal of Gynecological Research and Obstetrics 9, no. 1 (February 8, 2023): 007–019. https://doi.org/10.17352/jgro.000120.
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Bosire, Claire, Adriana C. Vidal, Jennifer S. Smith, Dereje Jima, Zhiqing Huang, David Skaar, Fidel Valea, et al. “Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia.” Infect Agent Cancer 16, no. 1 (June 13, 2021): 42. https://doi.org/10.1186/s13027-021-00382-3.
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Fuemmeler, Bernard F., Mikhail G. Dozmorov, Elizabeth K. Do, Junfeng Jim Zhang, Carole Grenier, Zhiqing Huang, Rachel L. Maguire, Scott H. Kollins, Cathrine Hoyo, and Susan K. Murphy. “DNA Methylation in Babies Born to Nonsmoking Mothers Exposed to Secondhand Smoke during Pregnancy: An Epigenome-Wide Association Study.” Environ Health Perspect 129, no. 5 (May 2021): 57010. https://doi.org/10.1289/EHP8099.
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Keyhan, Sanaz, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, et al. “Male obesity impacts DNA methylation reprogramming in sperm.” Clin Epigenetics 13, no. 1 (January 25, 2021): 17. https://doi.org/10.1186/s13148-020-00997-0.
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Murphy, Susan, Regina Whitaker, Gregory Sfakianos, Andrew Berchuck, and Zhiqing Huang. “Gene Expression using Affymetrix Human Genome U133 Plus 2 Arrays from 16 Primary and Recurrent Serous Epithelial Ovarian Cancers,” January 15, 2021. https://doi.org/10.7924/r43f4sx2k.
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Murphy, Susan, Gregory Sfakianos, Regina Whitaker, Andrew Berchuk, and Zhiqing Huang. “Primary and recurrent (second-look surgery) serous epithelial ovarian cancers Illumina Infinium HumanMethylation450 BeadChip data,” January 8, 2021. https://doi.org/10.7924/r4765hq57.
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Huang, Zhiqing, Eiji Kondoh, Zachary R. Visco, Tsukasa Baba, Noriomi Matsumura, Emma Dolan, Regina S. Whitaker, et al. “Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance.” Mol Cancer Ther 20, no. 1 (January 2021): 85–95. https://doi.org/10.1158/1535-7163.MCT-20-0119.
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Visco, Zachary R., Gregory Sfakianos, Carole Grenier, Marie-Helene Boudreau, Sabrina Simpson, Isabel Rodriguez, Regina Whitaker, et al. “Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.” Front Oncol 11 (2021): 620873. https://doi.org/10.3389/fonc.2021.620873.
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Batinic-Haberle, Ines, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, and Angeles Alvarez Secord. “H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways.” Oxid Med Cell Longev 2021 (2021): 6653790. https://doi.org/10.1155/2021/6653790.
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Acharya, K. S., R. Schrott, C. Grenier, Z. Huang, Z. Holloway, A. Hawkey, E. D. Levin, and S. K. Murphy. “Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).” Scientific Reports 10, no. 1 (December 1, 2020). https://doi.org/10.1038/s41598-020-69204-