Overview
Friederike Jayes, DVM, PhD, is an Assistant Professor in the Division of Reproductive Sciences in the Department of Obstetrics and Gynecology at Duke University Medical Center.
Dr. Jayes’ research centers on uterine fibroids and strategies for treatment — in particular, engineering smart injectable drug delivery theranostics for uterine fibroids. She also works extensively on effective mentoring. In July 2019, Dr. Jayes received funding as Duke’s Principal Investigator for a five-year NIH consortium grant titled "The Science of Mentoring, Networking and Navigating Career Transition Points." The grant was received through the National Research Mentoring Network.
Featured Article
Publications
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Corder, Ria D., Sashi V. Gadi, Robert B. Vachieri, Friederike L. Jayes, John M. Cullen, Saad A. Khan, and Darlene K. Taylor. “Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion.” Acta Biomater 134 (October 15, 2021): 443–52. https://doi.org/10.1016/j.actbio.2021.08.003.
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Singh, Bhuchitra, Holly Sims, Irene Trueheart, Khara Simpson, Karen C. Wang, Kristin Patzkowsky, Thomas Wegman, et al. “A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids.” Reprod Sci 28, no. 9 (September 2021): 2699–2709. https://doi.org/10.1007/s43032-021-00573-8.
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Islam, Md Soriful, Sadia Afrin, Bhuchitra Singh, Friederike L. Jayes, Joshua T. Brennan, Mostafa A. Borahay, Phyllis C. Leppert, and James H. Segars. “Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids.” Clin Transl Med 11, no. 7 (July 2021): e475. https://doi.org/10.1002/ctm2.475.
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Bickhaus, Jennifer A., Matthew O. Fraser, Alison C. Weidner, Friederike L. Jayes, Cindy L. Amundsen, Ken Gall, Frank C. Marini, Stanley J. Robboy, and Nazema Y. Siddiqui. “Evaluation of Host Immune Cellular and Extracellular Matrix Responses to Prolapse Mesh With and Without Tension in a Rat Model.” Female Pelvic Med Reconstr Surg 27, no. 2 (February 1, 2021): e385–91. https://doi.org/10.1097/SPV.0000000000000943.
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Bickhaus, Jennifer A., Matthew O. Fraser, Alison C. Weidner, Friederike L. Jayes, Cindy L. Amundsen, Ken Gall, Andrew T. Miller, Frank C. Marini, Stanley J. Robboy, and Nazema Y. Siddiqui. “Polycarbonate Urethane Mesh: A New Material for Pelvic Reconstruction.” Female Pelvic Med Reconstr Surg 27, no. 2 (February 1, 2021): e469–75. https://doi.org/10.1097/SPV.0000000000000964.
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Leppert, Phyllis C., Ayman Al-Hendy, Donna D. Baird, Serdar Bulun, William Catherino, Darlene Dixon, Merrick Ducharme, et al. “Summary of the Proceedings of the Basic Science of Uterine Fibroids Meeting: New Developments February 28, 2020.” F S Sci 2, no. 1 (February 2021): 88–100. https://doi.org/10.1016/j.xfss.2020.11.001.
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Islam, Md Soriful, Friederike L. Jayes, Bhuchitra Singh, Joshua T. Brennan, Phyllis C. Leppert, and James H. Segars. “COLLAGENASE CLOSTRIDIUM HISTOLYTICUM-TREATED UTERINE FIBROIDS SHOW REDUCTION OF TISSUE STIFFNESS AND CELL PROLIFERATION, AND INDUCTION OF CELL DEATH THROUGH AUTOPHAGY AND NECROPTOSIS, AND ALTERATION OF HIPPO SIGNALING.” In Fertility and Sterility, 114:E86–E86, 2020.
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Jayes, Friederike L., Betty Liu, Liping Feng, Nydea Aviles-Espinoza, Sergey Leikin, and Phyllis C. Leppert. “Evidence of biomechanical and collagen heterogeneity in uterine fibroids.” Plos One 14, no. 4 (2019): e0215646. https://doi.org/10.1371/journal.pone.0215646.
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Feng, Liping, Friederike L. Jayes, Lauren N. C. Johnson, David W. Schomberg, and Phyllis C. Leppert. “Biochemical Pathways and Myometrial Cell Differentiation Leading to Nodule Formation Containing Collagen and Fibronectin.” Curr Protein Pept Sci 18, no. 2 (2017): 155–66. https://doi.org/10.2174/1389203717666160322145731.
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Jayes, Friederike L., Betty Liu, Franklin T. Moutos, Maragatha Kuchibhatla, Farshid Guilak, and Phyllis C. Leppert. “Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.” Am J Obstet Gynecol 215, no. 5 (November 2016): 596.e1-596.e8. https://doi.org/10.1016/j.ajog.2016.05.006.