Investigators in the Reproductive Sciences Research Program are focused on a broad range of topics related to reproductive health, including:  

  • Placental development and function
  • Placental immunology
  • Pre-eclampsia
  • Prematurity
  • Uterine fibroids
  • Ovarian cancer
  • Cervical cancer
  • Uterine contractility and abnormal labor
  • Urinary microbiome
  • Overactive bladder
  • Epigenetics and epigenomics of gynecologic health and disease
  • Imprinted genes in reproductive health and outcomes
  • Impacts of the preconception environment

In addition to studies using human specimens and data, we use a number of model systems, including for example:

In vitro models:

  • Placental trophoblast cell lines, stem cells, primary cells and placental barrier-on-a-chip. 
  • Organoid models of ovarian cancer
  • Stem cell model of spermatogenesis

In vivo models:

  • Rabbit and rat model of reproductive health and the health of offspring including immune function and neurobehavioral development. 
  • Rat model of ovarian cancer
  • Mouse models of ovarian cancer